HOME >> BIOLOGY >> NEWS
MIT IDs link between brain tumor proteins

CAMBRIDGE, Mass. -- MIT researchers have identified a critical link between two proteins found in brain tumors, a discovery that could eventually help treat a form of brain cancer that kills 99 percent of patients.

Glioblastoma multiforme (GBM), the most aggressive brain tumor in adults, strikes about 15,000 people in the United States each year. GBM is currently treated with a combination of surgery, radiation and chemotherapy, but those treatments have proven ineffective. Most patients die within a year.

Now, MIT scientists have uncovered a connection between two proteins found in the tumor cells, and they have demonstrated that attacking both of those proteins kills tumor cells much more effectively than targeting either one alone.

The researchers, led by Forest White, MIT associate professor of biological engineering, report their findings in the early online edition of the Proceedings of the National Academy of Sciences for the week of July 16-20.

Their work could guide drug developers seeking treatments for GBM, which has proven resistant to all drugs that have been tried against it.

The team focused on a protein called EGFRvIII, a mutated form of the cell receptor for epidermal growth factor (EGF). The mutated receptor, which is found in approximately a quarter of GBM tumors, is continuously active and relentlessly pushes cells to keep growing and dividing.

Doctors have tried treating GBM patients with drugs that inhibit EGFRvIII, but they have had little effect. This could be because the continuous stimulation of the receptor is so intense and because the receptor interacts with numerous other proteins that also promote tumor growth, said White, who is also affiliated with MITs Center for Cancer Research and its Computational and Systems Biology Initiative.

The researchers believe it is the cumulative action of EGFRvIII and those other proteins that leads to tumor growth.

It
'"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
19-Jul-2007


Page: 1 2

Related biology news :

1. New textbook illuminates the close links between evolutionary and molecular biology
2. Link between sunspots, rain helps predict disease in east Africa
3. Link identified between Alzheimers disease and glaucoma
4. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
5. Human knowledge is based upon directed connectivity between brain areas
6. First case of successful ovarian tissue transplantation between two, nonidentical sisters
7. Strength of connections between brain regions may affect an adolescents response to peer influence
8. Co-operation between GSF and clinic improves outlook for sarcoma patients
9. FDA finds no strong link between tomatoes and reduced cancer risk
10. Link between immune system and mammary gland could shed new light on breast cancer
11. Satellite images reveal link between urban growth and changing rainfall patterns

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life Sciences , ... announces a new solution to manage regulated workloads on Microsoft Azure. , Regulated ... stack complies with FDA and global regulations. USDM's new managed service for regulated ...
(Date:7/18/2020)... ... 2020 , ... Commercial launch readiness is a critical stage in a product ... or vaccine, the global economic downturn will only increase price pressures overall for the ... capturing full value from every product launch is critical. However, history shows that only ...
(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass ... is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory ... at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... sciences industry, today announced the release of its signature product called Beacon ... Liaisons (MSLs) and other field medical professionals. , Beacon helps MSLs ...
(Date:7/18/2020)... MILWAUKEE (PRWEB) , ... July 16, 2020 , ... “We ... at Third Wave Bioactives. “It’s the only technology of its kind on the market ... flavor of onions with the protective capacity of traditional cultured ingredients, creating a natural ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, a ... laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and virus-management ...
(Date:7/10/2020)... Mass. (PRWEB) , ... July 09, 2020 , ... ... approaches to cell therapy, today announced the hiring of Allen R. Nissenson, M.D., ... team and oversee the clinical development of Sentien’s lead product, SBI-101. Dr. ...
Breaking Biology Technology:
Cached News: