HOME >> BIOLOGY >> NEWS
MIT creates 3-D scaffold for growing stem cells

d to and supported by the cells, other structures and proteins around them. A cell's normal environment is a complex network of tiny fibers, gaps and pores through which oxygen, hormones and nutrients are delivered and waste products filtered away. Cells move within their natural environments in response to chemical signals or other stimuli.

Researchers are aware that cells on flat surfaces have skewed metabolisms, gene expression and growing patterns. But the only choices have been glass labware and a product called Matrigel, a gelatinous protein mixture secreted by mouse tumor cells. While Matrigel does resemble a complex extracellular environment, it also contains growth factors and unknown proteins that limit its desirability for experiments requiring precise conditions.

"Synthetic biopolymer microfiber scaffolds have been studied for more than 30 years to mimic a living 3D microenvironment, but concerns exist about their degradation products and chemicals," the authors wrote in the paper.

Other synthetic polymer biomaterials are simply too big. Getting cells to grow on them is like forcing spiders to build webs on skyscraper girders. Zhang's nanofiber scaffold, around 1,000 times smaller than the existing systems, is much closer in size to the extracellular matrices that living cells manufacture themselves.

Adding motifs

With the addition of defined amino acid fragments called active motifs, the scaffold can be fashioned to coax stem cells to behave in certain desirable ways-such as differentiating into needed body tissues or migrating toward bone marrow and other natural destinations.

"What makes these designer scaffolds particularly interesting is that cells survive longer and differentiate better without additional soluble growth factors," Zhang said. "This suggests that extracellular microenvironments may play a more important role for cell survival and for carrying out cell functions than previ
'"/>

Contact: Elizabeth A. Thomson
thomson@mit.edu
617-258-5402
Public Library of Science
26-Dec-2006


Page: 1 2 3

Related biology news :

1. MIT creates 3-D images of living cell
2. Fusing imaging technologies creates synergy, helps diagnose heart disease accurately
3. Harvard team creates spray drying technique for TB vaccine
4. How badger culling creates conditions for spread of bovine TB
5. Climate change creates dramatic decline in red-winged black bird population
6. Purdue creates new low-cost system to detect bacteria
7. Brazil creates buffer zone around coral reefs off Atlantic coast
8. Penn researchers discover gene that creates second skeleton
9. Student creates material with multi-patterned surface to study tissue growth
10. Enzyme action creates protein linked to Alzheimers disease
11. Device creates electricity and treats wastewater

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
Breaking Biology News(10 mins):
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... ... from thermal denaturation in a cellular milieu; however, the broad application of this ... of simple platforms with sensitive quantitative readouts. Cell-based thermal stabilization assays are valuable ...
(Date:4/21/2017)... ... 21, 2017 , ... The University of Connecticut, in partnership ... three startups through the UConn Innovation Fund. The $1.5 million UConn Innovation Fund ... UConn. , The UConn Innovation Fund provides investments of up to $100,000 to ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick Innovative Technology Center, ... emerging technology-based businesses, recently earned a $77,518 grant from the Rural Maryland Council ... 2004, FITCI is Frederick’s first incubator. A non-profit corporation, FITCI is a public-private ...
(Date:4/20/2017)... ... April 20, 2017 , ... USDM Life Sciences , the leading risk ... industries, is pleased to announce Holger Braemer as Vice President of its ... based in Germany. , Braemer is an integral part of USDM’s expansion of ...
Breaking Biology Technology:
Cached News: