HOME >> BIOLOGY >> NEWS
MIT creates 3-D scaffold for growing stem cells

d to and supported by the cells, other structures and proteins around them. A cell's normal environment is a complex network of tiny fibers, gaps and pores through which oxygen, hormones and nutrients are delivered and waste products filtered away. Cells move within their natural environments in response to chemical signals or other stimuli.

Researchers are aware that cells on flat surfaces have skewed metabolisms, gene expression and growing patterns. But the only choices have been glass labware and a product called Matrigel, a gelatinous protein mixture secreted by mouse tumor cells. While Matrigel does resemble a complex extracellular environment, it also contains growth factors and unknown proteins that limit its desirability for experiments requiring precise conditions.

"Synthetic biopolymer microfiber scaffolds have been studied for more than 30 years to mimic a living 3D microenvironment, but concerns exist about their degradation products and chemicals," the authors wrote in the paper.

Other synthetic polymer biomaterials are simply too big. Getting cells to grow on them is like forcing spiders to build webs on skyscraper girders. Zhang's nanofiber scaffold, around 1,000 times smaller than the existing systems, is much closer in size to the extracellular matrices that living cells manufacture themselves.

Adding motifs

With the addition of defined amino acid fragments called active motifs, the scaffold can be fashioned to coax stem cells to behave in certain desirable ways-such as differentiating into needed body tissues or migrating toward bone marrow and other natural destinations.

"What makes these designer scaffolds particularly interesting is that cells survive longer and differentiate better without additional soluble growth factors," Zhang said. "This suggests that extracellular microenvironments may play a more important role for cell survival and for carrying out cell functions than previ
'"/>

Contact: Elizabeth A. Thomson
thomson@mit.edu
617-258-5402
Public Library of Science
26-Dec-2006


Page: 1 2 3

Related biology news :

1. MIT creates 3-D images of living cell
2. Fusing imaging technologies creates synergy, helps diagnose heart disease accurately
3. Harvard team creates spray drying technique for TB vaccine
4. How badger culling creates conditions for spread of bovine TB
5. Climate change creates dramatic decline in red-winged black bird population
6. Purdue creates new low-cost system to detect bacteria
7. Brazil creates buffer zone around coral reefs off Atlantic coast
8. Penn researchers discover gene that creates second skeleton
9. Student creates material with multi-patterned surface to study tissue growth
10. Enzyme action creates protein linked to Alzheimers disease
11. Device creates electricity and treats wastewater

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT creates scaffold for growing stem cells

(Date:4/14/2015)... 14, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... 2015 New York Design Awards under the category  ,Product ... City Design Awards are part of a global multi-disciplinary ... ratings from the marketplace, industry and judging panel. Winners ...
(Date:4/10/2015)... , April 10, 2015 ... addition of the "Security Competitive Profiles - NEC" ... http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to supply ... to the market, with a company focus on the ... anticipated. Winning opportunities in the ...
(Date:4/6/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... focused on the growing mobile commerce market, announced ... for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM ... NXT-ID introduces a new revolutionary method and system ... use of miniature antenna modules for multiple purposes ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
(Date:4/21/2015)... April 21, 2015 The North ... in 2014 to $605.1 million by 2019, at a ... Browse through the TOC of North ... of the industry trends and segments, with help of ... Early buyers will receive 10% customization ...
(Date:4/21/2015)... , April 21, 2015 Merrimack Pharmaceuticals, ... from a multi-arm Phase 1 study of MM-141, a ... presented in an oral session by Dr. Mansoor ... Cancer Research Annual Meeting in Philadelphia, PA. ... of MM-141 as a monotherapy and in combination with ...
(Date:4/21/2015)... PROVO, Utah , April 21, 2015  Tute Genomics, ... the hiring of Josh Forsythe as VP of ... that has witnessed a significant expansion in its commercial operations ... " Josh Forsythe is a ... Robison , MD MBA, CEO of Tute Genomics. "Josh,s vast ...
(Date:4/21/2015)... York (PRWEB) April 21, 2015 Progyny, ... Fertility Authority, LLC, announced that it has secured additional ... (KPCB), TPG Biotech, SR One and Merck Serono Ventures. ... to provide patients the best fertility outcomes by aligning ... the largest online marketplace for families seeking fertility solutions ...
Breaking Biology Technology:North America Biostimulants Market is Expected to Reach $605.1 Million by 2019, at a CAGR of 14.1% From 2014 to 2019 2North America Biostimulants Market is Expected to Reach $605.1 Million by 2019, at a CAGR of 14.1% From 2014 to 2019 3First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 2First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 3First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 4First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 5Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 4Announcing Progyny: Combining Best-in-Class Clinical Solutions with Consumer Expertise 2
Cached News: