HOME >> BIOLOGY >> NEWS
MIT model could predict cells' response to drugs

CAMBRIDGE, MA, July 27MIT researchers have developed a model that could predict how cells will respond to targeted drug therapies. Models based on this approach could help doctors make better treatment choices for individual patients, who often respond differently to the same drug, and could help drug developers identify the ideal compounds on which to focus their research.

In addition, the model could help test the effectiveness of drugs for a wide range of diseases, including various kinds of cancer, arthritis and immune system disorders, according to Douglas Lauffenburger, MIT professor of biological engineering and head of the department. Lauffenburger is senior author of a paper on the new model that will appear in the Aug. 2 issue of Nature.

The model is based on similarities in the signaling pathways cells use to process information. Those pathways translate cells' environmental stimuli, such as hormones, drugs or other molecules, into action.

"Cells undertake behavioral functions-proliferation, differentiation, death-in response to stimuli in their environment," said Lauffenburger. "The signaling pathways are the biomolecular circuits that process that information from the environment and regulate the mechanisms that execute the behavorial functions."

The pathways work via a series of signals in which proteins, known as kinases, activate other cell machinery to achieve a specific result, e.g., expression of certain genes, or actions of cytoskeletal proteins. While the same stimuli can produce diverse responses in different types of cells, the researchers believe they can use the same core pathways to achieve various end results.

Lauffenburger compared a cell's strategy to playing a piano: Just as there are 88 keys that can be played in a vast number of combinations to produce different melodies, cells can use their multiple pathways together in many different combinations to produce different behaviors.'"/>

Contact: Patti Richards
prichards@mit.edu
617-253-8923
Massachusetts Institute of Technology
30-Jul-2007


Page: 1 2

Related biology news :

1. Huntingtons disease study shows animal models on target
2. Stem cell therapy rescues motor neurons in ALS model
3. Drug protects brain cells in Huntingtons disease model, researchers find
4. New model for autism suggests women carry the disorder and explains age as a risk factor
5. New treatment model for HIV
6. A first-principles model of early evolution
7. Virginia Tech researchers to study poplar tree as model biomass crop
8. Scripps research scientists show protein accelerates breast cancer progression in animal models
9. Better chemistry through living models
10. Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model
11. New mouse model closely mimics human cancers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a ... most common and aggressive adult brain cancer—announced today the appointments of its first ... charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows are ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, a Scottish ... supplier and manufacturer of innovative portable renewable energy equipment, have announced the success ... the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable solar ...
(Date:6/19/2020)... SAN DIEGO (PRWEB) , ... ... ... host a three-part webinar series, “Automate Your Lab with Software for Data ... engineers. Attendees will learn how to integrate and automate cutting-edge scientific instruments ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and ... can drive one or two switches in a push-pull configuration; yielding fast fall ...
(Date:7/31/2020)... ... July 29, 2020 , ... The ... centers in 16 countries, has reached its 20th anniversary of worldwide use. Introduced ... use at top universities including University of Pennsylvania, University of Michigan, University of ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said Matt Hundt, ... market and we were pleased that the IFT jury recognized that.” reFRESH™ couples the ... natural way to extend the shelf life and improve the safety of perishable foods ...
(Date:7/10/2020)... (PRWEB) , ... July 09, ... ... biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has expanded ... broader license allows PathSensors to move into the point-of-care diagnostic market, focusing ...
Breaking Biology Technology:
Cached News: