HOME >> BIOLOGY >> NEWS
MIT particles pave way for new bedside diagnostics

CAMBRIDGE, Mass.--MIT researchers have created an inexpensive method to screen for millions of different biomolecules (DNA, proteins, etc.) in a single sample-a technology that could make possible the development of low-cost clinical bedside diagnostics.

The work, based on tiny customizable particles, could also be used for disease monitoring, drug discovery or genetic profiling. Even though the particles are thinner than the width of a human hair, each is equipped with a barcoded ID and one or more probe regions that turn fluorescent when they detect specific targets in a test sample.

Using a new, extremely versatile technique, the researchers can produce a "virtually unlimited" array of particles to test for DNA, RNA, proteins and other biomolecules, said Daniel Pregibon, a graduate student in chemical engineering at MIT.

Pregibon is the lead author of a paper on the work that will appear in the March 9 issue of Science.

He and co-author Patrick Doyle, the Doherty Associate Professor of Chemical Engineering, believe their particles could become an effective and inexpensive way to perform medical diagnostic tests at a patient's bedside.

Current testing methods are cost-prohibitive for bedside use, Pregibon said. The MIT particles are inexpensive to manufacture, and their results are as accurate, if not more so, than the results from more expensive systems, he said.

The particles offer a new way to do "multiplexed detection"-testing a single sample for multiple targets. In the laboratory, a common (but expensive) multiplexing technique involves a planar microarray-a flat surface with many spotted probes that each test for different targets. The MIT researchers are taking this approach away from planar surfaces onto free-floating particles.

With the tiny particles, it is much easier to custom-design each biological test, said Doyle. "It's very easy to tailor what you give a customer. You could
'"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
8-Mar-2007


Page: 1 2 3

Related biology news :

1. Gold nanoparticles may pan out as tool for cancer diagnosis
2. Under magnetic force, nanoparticles may deliver gene therapy
3. UCSB researchers show how to make polymeric micro- and nanoparticles
4. Soil particles found to boost prions capacity to infect
5. Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery
6. Pairing nanoparticles with proteins
7. Nanoparticles carry chemotherapy drug deeper into solid tumors
8. In nature, proteins sweep up nanoparticles
9. Bacteria ferry nanoparticles into cells for early diagnosis, treatment
10. MU researchers examine the environmental effects of silver nanoparticles
11. Work with nanoparticles may lead to on-the-spot virus detector

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... (PRWEB) , ... August 28, ... ... (Diagnostic Assessment and Clinical Research Organization), have recently passed their five-year ... standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary focus towards ...
(Date:8/27/2019)... ... August 27, 2019 , ... e3 Diagnostics, the nation’s ... it has partnered with Bertec, a leading manufacturer of force measurement devices for ... a full line of clinical systems for both assessment and treatment of balance ...
(Date:8/27/2019)... ... 2019 , ... Advancements with Ted Danson will focus on ... broadcast 4Q/2019. Check local listings for more information. , This segment of ... show will highlight how Debiopharm is working to champion the synergy between therapeutic ...
Breaking Biology News(10 mins):
(Date:8/29/2019)... ... 28, 2019 , ... DuPont Nutrition & Biosciences will offer ... the International Baking Industry Expo, September 8 to 11, in booth 5015. DuPont ... cost and waste reduction and from maintaining freshness throughout shelf life to reformulating ...
(Date:8/23/2019)... Wis. (PRWEB) , ... August 22, 2019 , ... The ... some of the most harmful germs and pathogens on hard surfaces including E. Coli, ... leaves behind no chemical residues. For more information, visit the product page at rovingblue.com ...
(Date:8/8/2019)... FRANCISCO (PRWEB) , ... August 08, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced that the ... Value Leadership Award for the IVA market . Inference will officially accept the ...
(Date:8/6/2019)... ... August 06, 2019 , ... The National Science Foundation ... a community project that will engage middle and early high school students in ... Youth-Led Citizen Science Network for Community Environmental Assessment.” Collaborative partners presenting the authentic ...
Breaking Biology Technology:
Cached News: