MIT study shows genetic link for sch...( This study provides genetic and biolo...)

MIT study shows genetic link for schizophrenia

This study provides genetic and biological evidence that PPP3CC and EGR3, both constituents of the calcineurin signaling pathway, may independently elicit increased risk for schizophrenia, said co-author Susumu Tonegawa, Picower Professor of Biology and Neuroscience at MIT. These findings raised a novel and potentially important role for EGR genes in schizophrenia pathogenesis.

In addition to Yoshikawa and Tonegawa, authors are Kazuo Yamada, Yoshimi Iwayama, Tetsuo Ohnishi, Hisako Ohba, Tomoko Toyota and Jun Aruga of RIKEN Brain Sciences Institute; David J. Gerber of the Howard Hughes Medical Institute and the RIKEN-MIT Neuroscience Research Center; and Yoshio Minabe of Kanazawa University School of Medicine in Japan.

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
19-Feb-2007

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