HOME >> BIOLOGY >> NEWS
MNI researchers find a new role for mitochondria in cellular copper regulation

Copper is an essential part of our lives. From copper pipes and wires - to important copper-containing proteins in the body, copper is necessary for healthy growth and neurological development. Researchers at the Montreal Neurological Institute at McGill University are studying how copper is processed in our bodies and its distinct role in early development. Their findings, published in a recent edition of the journal Cell Metabolism, identify a new role for two proteins involved with copper regulation. This study may lead to a better understanding of how to treat individuals affected by copper imbalances.

"Copper is important in maintaining healthy cells. When copper is not properly regulated in the body it can lead to diseases of the liver, kidneys, brains and eyes," says Dr. Eric Shoubridge, a professor of Human Genetics at the Montreal Neurological Institute, McGill University and lead investigator. "We know that copper is especially important in early development, playing a vital role in the proper formation of organs. Mutations in two copper-carrying proteins, SCO1 and SCO2 have been implicated in a number of neonatal diseases."

Copper is required for the activity of a number of enzymes including cytochrome c oxidase (COX) in the mitochondria -the energy suppliers of the body. "Our study is the first to characterize an unexpected cell-signaling or messenger role for the two copper-carrying proteins, SCO1 and SCO2, which are necessary for the assembly of COX," says Shoubridge.

To characterize the roles of SCO1 and SCO2, Shoubridge and colleagues looked at cells that contained mutated forms of either one or both of these molecules. The study shows that both proteins have a role in maintaining the balance of copper between different cellular compartments. "These findings add two members to a growing list of bi-functional proteins that participate in copper metabolism." adds Shoubridge. "Identifying this new role for SCO1 and
'"/>

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
Montreal Neurological Institute and Hospital
1-May-2007


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/8/2019)... ... 2019 , ... PureWay, a healthcare-focused provider of sharps disposal, ... head of sales and business development efforts, effective immediately. Mr. Kennedy will report ... for Johnson & Johnson Medical, Globus Medical, WRP Asia Pacific, and Stryker, all ...
(Date:1/7/2019)... OAKLAND, Calif. (PRWEB) , ... January 07, 2019 ... ... Artificial Intelligence (AI) and leading supplier of Graph Database technology for Knowledge Graphs ... (DBTA) as a 2019 ‘Trend-Setting’ Product . DBTA’s data and information ...
(Date:1/4/2019)... N WHITEHOUSE, N.J. (PRWEB) , ... January 03, ... ... begun to rapidly adopt 3D cell culture models into their drug discovery research ... While these models improve the in vivo relevancy of in vitro studies, they ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... January 29, 2019 , ... ... Organization (CDMO) serving the global biopharmaceutical and biotechnology industries with sites in China ... backed by multiple global investors lead by China's State Development & Investment Corporation ...
(Date:1/30/2019)... ... 2019 , ... The Society for Laboratory Automation and Screening ... practices for laboratory automation and screening. This year the conference will be held ... will be at booth #345 and throughout the conference will highlight its unique ...
(Date:1/24/2019)... Calif. (PRWEB) , ... January 22, 2019 , ... Dr. ... using the Pall Veterinary Platelet Enhancement Therapy System (V-PET™) for nearly three ... VetStem Regenerative Cell Therapy since 2007 and began using V-PET™ 2016. ...
(Date:1/20/2019)... , ... January 17, 2019 , ... ... was, until recently, the exclusive purview of physicians. That's changing as many services ... direct to consumer (DTC) laboratory testing market totaled $208 million in 2018, according ...
Breaking Biology Technology:
Cached News: