HOME >> BIOLOGY >> NEWS
MRI study opens door to assessing, preventing dangerous brain iron levels

A magnetic resonance imaging (MRI) study at UCLA opens new doors to assessing and potentially preventing brain iron accumulation associated with risk of developing degenerative brain diseases such as Alzheimer's, Parkinson's and Dementia With Lewy Bodies.

Posted as an early online publication of the peer-reviewed journal Neurobiology of Aging, this largest-ever study of brain iron demonstrates gender difference in brain iron levels for the first time. Until now, researchers had considered the brain blood barrier as protection against accumulating too much iron from the body. The finding suggests instead that age-related brain iron accumulation is a modifiable risk factor for degenerative brain diseases.

In addition, the study finds a nearly perfect correlation between iron levels in various brain regions of study participants measured using MRI and those reported by past post-mortem studies. The finding demonstrates the ability of MRI analysis to accurately measure iron levels in brain tissues of living patients.

Previous studies have shown that high accumulation of iron in brain tissue causes oxidative damage and formation of plaques found in age-related neurodegenerative disorders such as Alzheimer disease. In addition, past population studies show men develop such diseases about five years earlier than women but brain iron levels increase with age in both genders.

"If you can measure it and learn how to modify it, then you can fix it," said Dr. George Bartzokis, lead author and professor of neurology at the David Geffen School of Medicine at UCLA. "Alzheimer disease rates double every five years after age 60, so a modifiable risk factor assessed by non-invasive means may represent potential interventions that could halve the number of cases of AD in the United States."

The UCLA team measured iron stored in ferritin molecules in the brain tissues of living subjects with MRI by using the Field Dependent Relaxation Rate Incr
'"/>

Contact: Dan Page
dpage@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
24-Mar-2006


Page: 1 2

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. A study by the MUHC and McGill University opens a new door to understanding cancer
5. New study suggests Concord grape juice may provide protection against breast cancer
6. Preclinical study links gene to brain aneurysm formation
7. In limiting life span, study finds booming bacteria innocent
8. Multicenter study nets new lung tumor-suppressor gene
9. MIT study: Maturity brings richer memories
10. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
11. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: