HOME >> BIOLOGY >> NEWS
MSKCC researchers uncover structure of key protein complex in cells

Scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) have uncovered the structure of a network of proteins that help regulate the life cycle of cells. Understanding the network's physical layout is an important step toward learning its precise function, and in finding ways to correct flaws in the system that could lead to cancer.

Using x-ray crystallography, the researchers identified how one protein, a molecule called the Small Ubiquitin-related Modifier (SUMO-1), is connected or "conjugated" to another molecule within the complex. The findings, reported in the June 2, 2005, issue of Nature, offer the first complete look at the structure of these molecules as they are thought to exist in the cell.

"Understanding this process could be important in many physiological steps that are disrupted in cancer -- including error-prone DNA replication, chromosome segregation, the cell's response to stress, and normal signaling reactions," said Christopher Lima, PhD, a structural biologist at the Sloan-Kettering Institute and lead author of the study.

While there's no direct evidence that SUMO is important in cancer, research suggests that it is necessary for the normal assortment of chromosomes immediately before a cell splits. Yeast cells that lack SUMO cannot successfully divide, Dr. Lima noted.

Since cancer is characterized by cells dividing unchecked, proving SUMO's function could potentially yield novel anticancer therapies. "If sumoylation (when SUMO attaches to a protein) is promoting cell division, then inhibitors of SUMO may be a pretty good agent to block the cell cycle," said Dr. Lima.

Postdoctoral researcher David Reverter, PhD, collaborated with Dr. Lima on the work and is the first author on the Nature paper.

SUMO has been called a "mysterious cousin" of ubiquitin, a protein of increasing interest to cancer experts. The two molecules have remarkably similar structures, though they perform different tas
'"/>

Contact: Christine Hickey
hickey1@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
1-Jun-2005


Page: 1 2 3

Related biology news :

1. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
2. Innovative tagging technique may help researchers better protect fish stocks
3. Penn researchers discover how key protein stops inflammation
4. ASU researchers partner with UOP to make biofuel for military jets a reality
5. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
6. Penn researchers discover pathway that eliminates genetic defects in red blood cells
7. U-M researchers find family of on switches that cause prostate cancer
8. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
9. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
10. MGH researchers confirm that bone marrow restores fertility in female mice
11. Smithsonians National Zoo researchers use electronic eggs to help save threatened species

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2018)... (PRWEB) , ... August 06, 2018 , ... ... in front of The NCERC at Southern Illinois University Edwardsville’s University Park. SIUE ... also grain sorghum and sweet sorghum. These three feedstocks represent conventional biofuels production, ...
(Date:8/7/2018)... BOSTON and SOUTH JORDAN, Utah (PRWEB) , ... August 07, 2018 ... ... communications and collaboration solutions, announced today their new CT Cloud Voice and SIP solutions. ... cloud delivering a scalable and secure, quality voice solution that is far superior to ...
(Date:8/2/2018)... ... August 02, 2018 , ... RxS LLC (“RxS”), a ... today announced that Mark Jara, principal of the organization, has been named to ... industry. Individuals named to PharmaVOICE 100 are leaders who drive the industry forward ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... ... July 25, 2018 , ... Almac Clinical Technologies ... supplies data through its flagship IXRS® 3 Interactive Response Technology (IRT) ... podcast features both Almac thought leaders and outside experts discussing best practices relating ...
(Date:7/24/2018)... OMAHA, Neb. (PRWEB) , ... July 23, 2018 ... ... the impact of a biofield energy treated nutraceutical to increase immunity and improve ... well as, immune function response assessed in the preclinical research were significantly reduced. ...
(Date:7/24/2018)... ... 24, 2018 , ... Boval was founded in 1978 when Mr. Douglas Northcott ... Boval’s early days most of the BSA manufactured was for blood banking reagents; however, ... after gel cards changed that market and displaced most of the large volume needs. ...
(Date:7/22/2018)... , ... July 19, 2018 , ... ... driven channel professional has joined their team. With more than ten years of ... Adam will deliver his expertise as CallTower’s Channel Director for the Southwest and ...
Breaking Biology Technology:
Cached News: