HOME >> BIOLOGY >> NEWS
'Mad cow' proteins successfully detected in blood

GALVESTON, Texas -- Researchers at the University of Texas Medical Branch at Galveston (UTMB) have found a way to detect in blood the malformed proteins that cause "mad cow disease," the first time such "prions" have been detected biochemically in blood.

The discovery, reported in an article scheduled to appear online in Nature Medicine Aug. 28, is expected to lead to a much more effective detection method for the infectious proteins responsible for brain-destroying disorders, such as bovine spongiform encephalopathy (BSE) in cattle and variant Creutzfeldt-Jakob disease (vCJD) in humans. The blood test would make it much easier to keep BSE-infected beef out of the human food supply, ensure that blood transfusions and organ transplants do not transmit vCJD, and give researchers their first chance to figure out how many people may be incubating the disease.

"The concentration of infectious prion protein in blood is far too small to be detected by the methods used to detect it in the brain, but we know it's still enough to spread the disease," said UTMB neurology professor Claudio Soto, senior author of the Nature Medicine paper. "The key to our success was developing a technique that would amplify the quantity of this protein more than 10 million-fold, raising it to a detectable level."

Soto and the paper's other authors, UTMB assistant professor of neurology Joaquin Castilla and research assistant Paula Sa, applied a method they call protein misfolding cyclic amplification (PMCA) to blood samples taken from 18 prion-infected hamsters that had developed clinical symptoms of prion disease. PMCA uses sound waves to vastly accelerate the process that prions use to convert normal proteins to misshapen infectious forms.

Successive rounds of PMCA led to the discovery of prions in the blood of 16 of the 18 infected hamsters. No prions were found in blood samples that were taken from 12 healthy control hamsters and subjected to the same treat
'"/>


28-Aug-2005


Page: 1 2

Related biology news :

1. UCF research links proteins, stem cells and potential Alzheimers treatment
2. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
3. Unlocking proteins from their cellular shell
4. Call for EU to launch major project to map out all our proteins
5. MIT IDs link between brain tumor proteins
6. Protein pulling -- Learning how proteins fold by pulling them apart
7. Measuring the unseeable: Penn researchers probe proteins dark energy
8. New use for a cell toxin found to inhibit survival proteins in cancer cells
9. Pairing nanoparticles with proteins
10. Targeting key proteins of carcinogenesis
11. Autism-related proteins control nerve excitability, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... 2020 , ... Nine middle school teachers from eight states ... unique professional development program that provides advanced STEM (science, technology, engineering and math) ... , Created in partnership between the National Stem Cell Foundation and The Gatton ...
(Date:7/31/2020)... (PRWEB) , ... July 30, 2020 , ... ... Research (SBIR) Phase II contract awarded by the Joint Science & Technology Office—Chemical ... this project is to develop, optimize, and scale-up a highly efficient mammalian cell ...
(Date:7/18/2020)... ANTONIO (PRWEB) , ... July 16, 2020 , ... ... ONE that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise control ... environment. The study reported that the Neoasis™ device attenuated the alarm sounds from ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... , ... July 16, 2020 , ... ... to aid in the early detection and prevention of high-burden diseases, and Centric ... US-based hospitals and healthcare organizations to utilize existing data in order to identify ...
(Date:7/10/2020)... ... 2020 , ... Bode Technology, a leading provider ... through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical testing ... provides a turnkey solution that includes a comprehensive collection and virus-management program for ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using ... suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. ... has been using the zebrafish model to investigate the causes of leukaemia and ...
(Date:7/7/2020)... ... 2020 , ... R3 International is now offering stem cell therapy for Alzheimers ... Depending on the patient's condition, treatment may be offered IV, intrathecal or with a ... of Alzheimers dementia, and the incidence continues to increase as individuals live longer. There ...
Breaking Biology Technology:
Cached News: