HOME >> BIOLOGY >> NEWS
Major breakthrough in understanding how HIV interferes with infected cell division

Montral, July 12, 2007 Dr. ric A. Cohen, a researcher at the IRCM (Institut de recherches cliniques de Montral), and his team will publish on Friday, July 13, in PLoS Pathogens a discovery that could lead to the development of a new class of drugs to combat HIV.

Human immunodeficiency virus type 1 (HIV-1) causes AIDS by depleting essential immune cells called CD4+T lymphocytes in infected individuals, resulting in a compromised immune system. At the center of this process is the HIV protein, viral protein R (Vpr), which stops infected CD4+T cells from dividing and as a consequence compromises their immune function. In addition, by arresting cell division, Vpr helps HIV to harness the infected cells resources to enhance viral replication. The way Vpr exerts this effect is by interacting with cellular proteins that control cell division.

Dr. Cohen and his team have identified a novel cellular protein complex targeted by HIV-1 Vpr to stop infected cell division. This protein complex, designated DDB1-CUL4-VprBP, is involved in a process called ubiquitination. Ubiquitination is a mechanism by which a small protein called ubiquitin is conjugated to cellular proteins in order to modulate their biological activity or induce their degradation. The researchers demonstrated that association of Vpr with this ubiquitinating complex, also called an E3 ubiquitin ligase complex, is essential for the defect in cell division induced by Vpr. Further characterization of this protein complex as well as the elucidation of the mechanism by which it affects cell division may open new avenues for therapeutic intervention against HIV.


'"/>

Contact: Lucette Thriault
lucette.theriault@ircm.qc.ca
514-987-5535
Institut de recherches cliniques de Montreal
12-Jul-2007


Page: 1

Related biology news :

1. Major study predicts grim future for Europes seas
2. Major genetic study identifies clearest link yet to obesity risk
3. Major gene study uncovers secrets of leukemia
4. Major society publisher announces support for public access to scientific literature
5. Major link in brain-obesity puzzle found
6. Major Wellcome Trust award to take science from the bench to the bedside
7. Major breakthrough in the mechanism of myelin formation
8. Major new osteoporosis study to recruit people in Orkney
9. Major genetic risk factor found for prostate cancer
10. Major report on tigers to be released Thursday at National Zoo
11. Major initiative proposed to address amphibian crisis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/14/2019)... ... January 14, 2019 , ... CellMax ... cancer cells in blood, will present new findings at the ASCO Gastrointestinal Cancer ... colorectal cancer. The results from this study show CellMax Life’s blood test, based ...
(Date:1/10/2019)... (PRWEB) , ... January 09, 2019 , ... Dr. Beanlands ... Heart Institute in Ottawa, Ontario, Canada. He is also Director of its National ... of Medicine, in the Department of Radiology, and in the Department of Cellular and ...
(Date:1/10/2019)... ... 2019 , ... A major goal for pharmaceutical companies has ... significantly more expensive in vivo studies in order to reduce costs and improve ... researchers have begun to adopt 3D cell culture models which have been shown ...
Breaking Biology News(10 mins):
(Date:12/20/2018)... ... December 20, 2018 , ... New Year’s brings reflection ... changes in regulations in the European Union (EU) on the horizon, Jim Kasic, president ... , “The transition to the EU Medical Device Regulation (MDR), digital health, and big ...
(Date:12/18/2018)... ... December 18, 2018 , ... Patients with early stages of breast cancer who ... post-treatment versus whole breast irradiation, a new study suggests. , Patients with early stage ... irradiation after removal of the cancerous tumor because there is a 30 to 40 ...
(Date:12/13/2018)... ... December 13, 2018 , ... Microbial Discovery Group LLC (MDG) ... been part of their strategic plan and an important milestone in increasing their ... opportunities for MDG within the $44 Billion human probiotic market. This plan is ...
(Date:12/5/2018)... (PRWEB) , ... December 04, ... ... an established North American full-service contract research organization (CRO), announced the acquisition ... transaction significantly strengthens ARG’s reach and experience in the management of clinical ...
Breaking Biology Technology:
Cached News: