HOME >> BIOLOGY >> NEWS
Major genetic study identifies clearest link yet to obesity risk

Scientists have identified the most clear genetic link yet to obesity in the general population as part of a major study of diseases funded by the Wellcome Trust, the UK's largest medical research charity. People with two copies of a particular gene variant have a 70% higher risk of being obese than those with no copies.

Obesity is a major cause of disease, associated with an increased risk of type 2 diabetes, heart disease and cancer. It is typically measured using body mass index (BMI). As a result of reduced physical activity and increased food consumption, the prevalence of obesity is increasing worldwide. According to the 2001 Health Survey for England, over a fifth of males and a similar proportion of females aged 16 and over in England were classified as obese. Half of men and a third of women were classified as overweight.

Scientists from the Peninsula Medical School, Exeter, and the University of Oxford first identified a genetic link to obesity through a genome-wide study of 2,000 people with type 2 diabetes and 3,000 controls. This study was part of the Wellcome Trust Case Control Consortium, one of the biggest projects ever undertaken to identify the genetic variations that may predispose people to or protect them from major diseases. Through this genome-wide study, the researchers identified a strong association between an increase in BMI and a variation, or "allele", of the gene FTO. Their findings are published online today in the journal Science.

The researchers then tested a further 37,000 samples for this gene from Bristol, Dundee and Exeter as well as a number of other regions in the UK and Finland.

The study found that people carrying one copy of the FTO allele have a 30% increased risk of being obese compared to a person with no copies. However, a person carrying two copies of the allele has a 70% increased risk of being obese, being on average 3kg heavier than a similar person with no copies. Amongs
'"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
12-Apr-2007


Page: 1 2 3

Related biology news :

1. Major breakthrough in understanding how HIV interferes with infected cell division
2. Major study predicts grim future for Europes seas
3. Major gene study uncovers secrets of leukemia
4. Major society publisher announces support for public access to scientific literature
5. Major link in brain-obesity puzzle found
6. Major Wellcome Trust award to take science from the bench to the bedside
7. Major breakthrough in the mechanism of myelin formation
8. Major new osteoporosis study to recruit people in Orkney
9. Major genetic risk factor found for prostate cancer
10. Major report on tigers to be released Thursday at National Zoo
11. Major initiative proposed to address amphibian crisis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... 23, 2020 , ... First Aid Africa, a Scottish charity ... and manufacturer of innovative portable renewable energy equipment, have announced the success of ... COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable solar power ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku ... the next event in a series of TOPIQ webinars, which will cover the ... webinars was developed in response to social distancing measures that resulted in postponements ...
(Date:6/19/2020)... ... 16, 2020 , ... The director of stem cell biotechnology company Asymmetrex ... medicine and pharmaceutical industries have easier access to stem cell counting, they will soon ... this year, Independence Day weekend in the U.S., Asymmetrex is offering free tissue stem ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified ... systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... one or two switches in a push-pull configuration; yielding fast fall time for ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... and Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing ... announced that they have entered into a strategic partnership whereby Catalent will provide ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... 200 of the top radiation centers in 16 countries, has reached its 20th ... SDX® is now in routine use at top universities including University of Pennsylvania, ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed ... Manager Regulatory Solutions, in a one hour live webinar on Thursday, August ... in China for drugs and medical devices. Specifically, for medical devices, the NMPA has ...
Breaking Biology Technology:
Cached News: