HOME >> BIOLOGY >> NEWS
Major link in brain-obesity puzzle found

ANN ARBOR, Mich. A single protein in brain cells may act as a linchpin in the bodys weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, University of Michigan Medical School researchers report.

And although its far too early to say how this protein could be useful in new strategies to fight the worlds epidemic of obesity, the finding gives scientists an important system to target in future research and the development of anti-obesity medications.

In the February issue of the Journal of Clinical Investigation, U-M researcher Liangyou Rui, Ph.D. and his team report their findings on a protein called SH2B1, and specifically on its activity in brain cells.

Using a variety of genetic, diet and hormone techniques, they were able to show that the action of SH2B1 regulates body weight, the action of the metabolic signaling molecules leptin and insulin, and the use of energy from food. It even moderated the impact of a high-fat diet on body weight.

The experiments were performed in mice, including two types of mice that the team altered genetically so that they only expressed a unique form of the SH2B1 protein in their brain cells. The protein occurs elsewhere in the body, but the researchers were able to zero in on its activity in the hypothalamus: the area of the brain that coordinates signals from the brain and body relating to food, hunger, and the balance of energy and nutrients in the body.

Previously, Rui and his team have shown that mice that lack the gene for SH2B1 -- called knockout mice -- become obese, diabetic, and unable to stop eating. Their bodies lose the ability to sense the signals sent by leptin and insulin that tell the brain to slow down food intake and fat storage.

For the new paper, they looked at not only normal mice and mice that didnt have the SH2B1 gene, but also at mice that made SH2B1 only in brain
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
29-Jan-2007


Page: 1 2 3 4

Related biology news :

1. Major breakthrough in understanding how HIV interferes with infected cell division
2. Major study predicts grim future for Europes seas
3. Major genetic study identifies clearest link yet to obesity risk
4. Major gene study uncovers secrets of leukemia
5. Major society publisher announces support for public access to scientific literature
6. Major Wellcome Trust award to take science from the bench to the bedside
7. Major breakthrough in the mechanism of myelin formation
8. Major new osteoporosis study to recruit people in Orkney
9. Major genetic risk factor found for prostate cancer
10. Major report on tigers to be released Thursday at National Zoo
11. Major initiative proposed to address amphibian crisis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... 2020 , ... Today CJ BIO announced the first in a series of ... taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a ... July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT ...
(Date:7/1/2020)... SOMERSET, N.J. (PRWEB) , ... July 01, 2020 ... ... today announced that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility ... with the company’s existing Japanese clinical supply facility located in Kakegawa, the new ...
(Date:6/25/2020)... MANSFIELD, Mass. (PRWEB) , ... June 24, 2020 ... ... provider of cloud-based enterprise software and software-driven clinical data services that accelerate drug ... trials for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... 2020 , ... Regen Suppliers, the one stop shop for ... get the fourth unit free with no limit on the amniotic derived exosomes. ... have been a game changer for regenerative therapies. The products are manufactured at ...
(Date:6/23/2020)... ... June 23, 2020 , ... Nobilis Therapeutics, ... that it has filed an Investigational New Drug application (IND) with the U.S. ... its lead drug candidate NBTX-001 in patients with panic disorder (PD). , "Adding ...
(Date:6/11/2020)... HOUSTON (PRWEB) , ... June 08, 2020 , ... ... first universal vaccine platform delivered through the use of proprietary clean viral vectors, ... vaccine in the United States. Greffex’s platform is the world’s most successful ...
(Date:6/11/2020)... ... June 09, 2020 , ... ... the NEON Micro-Tracer Solution, a highly accurate, contact tracing solution for ... the workplace. Contact tracing, a core disease control measure, is a key strategy ...
Breaking Biology Technology:
Cached News: