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Malaria: The right vaccine in the right place?

FUP strains, the immunity stimulated by the vaccine might not be optimal. If this turns out to be the case, a FVO- or FUP-derived vaccine might be more effective in Mali than the 3D7-derived vaccine, though not necessarily elsewhere.

More generally, these results show the importance of determining the genetics of pathogen populations before starting vaccine trials. Without this information, a vaccines ability to prevent infections with specific parasite strains cannot be determined accurately and potentially useful vaccines might be abandoned if they are tested on inappropriate populations.

As Colin Sutherland (London School of Hygiene and Tropical Medicine) writes in an accompanying Perspective, this study provides ample warning that analysis of antigen diversity in the target population should be part of the intelligence gathering undertaken when planning intervention studies in the first place.


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Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
12-Mar-2007


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