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Malaria poses additional risks for first-time mothers

One of the consequences of malaria has been shown in new research to be an increased likelihood for women in their first pregnancy to develop preeclampsia (very high blood pressure and protein loss in the urine), which carries high risks for both mother and child.

Preeclampsia is thought to be more common in parts of the world where there is a serious malaria problem and it has often been speculated that there might be a connection. Malaria is more common in a first pregnancy and so is preeclampsia. In both cases, the reasons are unknown. Researchers from the USA, UK and Tanzania set out to investigate the possibility that malaria might lead to preeclampsia.

When a pregnant woman has malaria, it can result in a high concentration of malaria parasites developing in the placenta, in which case she is said to have 'placental malaria'. This is very harmful to the mother and to the fetus; it leads to low birth weight and, in Africa alone, is estimated to be responsible for the deaths of about 200,000 infants every year. A woman who is pregnant for the first time is most likely to suffer from placental malaria, and to have her placenta become highly infected and extremely inflamed. If she later becomes pregnant again, she will be protected to some extent by antibodies she has developed against the parasites in the placenta.

Working with pregnant women in Tanzania, the researchers found that, overall, women with placental malaria were no more likely than other women to develop hypertension. However, for young first-time mothers, having placental malaria increased the risk of hypertension about three-fold. The researchers also measured levels of a substance called sVEGFR1 (sometimes called sFlt1), which is known to increase before and during preeclampsia and is thus considered to be a 'biomarker' for the condition. sVEGFR1 levels were high in first-time mothers with either placental malaria or hypertension, or both, but levels were not r
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Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
13-Nov-2006


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