HOME >> BIOLOGY >> NEWS
Male-specific gene SRY directly controls neuronal function in the brain

Shaped by much previous research, the prevailing view regarding sex-specific differences in the brain is that they are caused by circulating sex hormones, which are generated outside the brain and influence certain aspects of brain development, as well as brain function in adults. But new findings, reported by a team including Dr. Eric Vilain of UCLA, now reveal a new dimension to the influence of sex determination on brain function. The research shows that a single sex-specific gene plays a direct role in the brain by acting in neurons themselves, in addition to exerting an influence on the brain from afar through the action of hormones.

The researchers show that the mammalian gene SRY, which is the key sex-determination gene that directs gonads to develop as testes rather than ovaries, is also required in males for the normal function of a particular set of neurons in the adult mouse brain. These neurons secrete the neurotransmitter dopamine in the substantia nigra, a brain region that degenerates in Parkinson's disease.

SRY is passed from father to son on the Y chromosome and is not present in females. It is particularly intriguing that a gene that acts specifically in one sex is essential for the proper function of a certain set of neurons in males.

The researchers speculate that males and females may have different ways of maintaining the function of dopaminergic neurons in the substantia nigra. SRY, a gene present only in males, may compensate for other mechanisms of protection that are possessed more by females than by men--such protection could be provided by estrogens or other female-associated factors. The authors of the study are presently testing this hypothesis.

A potential implication of the work is that it may help explain sex-specific differences that characterize Parkinson's disease, which is more frequent in males than females (exhibiting a 3:2 ratio in incidence). Also, sex differences in other behaviors or disorder
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
21-Feb-2006


Page: 1 2

Related biology news :

1. Gene variations directly link inflammation to an increased risk for lung cancer
2. New research links placenta praevia directly to assisted reproductive techniques
3. Learned motor programs directly influence the visual perception of movements
4. Individual differences in taste perception directly related to genetic variation in taste receptors
5. Researchers find local environment directly influences adult stem cell reservoirs
6. Circadian clock controls plant growth hormone
7. Researchers find pathway that controls cell size and division
8. Tiny molecule controls stress-induced heart disease
9. Molecular on/off switch controls immune defenses against viruses
10. Pair of microRNA molecules controls major oncogene in most common leukemia
11. Biodiversity controls ecological services, report scientists in comprehenisive analysis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2020)... ... June 18, 2020 , ... ... Your Lab with Software for Data Decisions,” for pharmaceutical and biotech executives, ... integrate and automate cutting-edge scientific instruments and laboratory equipment from dozens of ...
(Date:6/11/2020)... (PRWEB) , ... June 08, 2020 , ... ... for masks and other protective measures to protect workers in the medical field. ... their dedicated staffs who valiantly risk their lives every day to provide healthcare ...
(Date:6/5/2020)... CULVER CITY, Calif. (PRWEB) , ... June 04, 2020 , ... ... is for the health and well-being of our attendees, staff, and the public. ... there are unique and safe ways to collaborate virtually,” said Julie Sutcliffe, President of ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... , ... July 29, 2020 , ... ... announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption of ... and around the globe, requiring fast track capacity to provide patients with urgently ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and monitoring ... did not take off as quickly as people initially expected, and where eSource is ... data electronically for clinical trials and then repurposing it for downstream analysis, at a ...
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter ... of a successful study, while protecting and accessing the catheter or device post-surgery is ... from Envigo in a live webinar on Wednesday, August 5, ...
(Date:7/10/2020)... ... 08, 2020 , ... Bode Technology, a leading ... operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical ... provides a turnkey solution that includes a comprehensive collection and virus-management program ...
Breaking Biology Technology:
Cached News: