PITTSBURGH, May 18 Women who take antidepressants during the final trimester of pregnancy through delivery increase the risk of "neonatal behavioral syndrome," a constellation of symptoms and behaviors largely related to drug withdrawal or side effects, University of Pittsburgh researchers conclude in a review of medical literature. Such findings reveal an additional challenge for clinical management of depression during pregnancy, Eydie Moses-Kolko, M.D., assistant professor of psychiatry at the University of Pittsburgh School of Medicine, and her colleagues write in the May 18 issue of the Journal of the American Medical Association.
"The FDA and drug manufacturers recently agreed to label revisions for antidepressants known as selective serotonin reuptake inhibitors. Now the label for these drugs includes information about potential adverse effects to newborns if the drug is taken late in pregnancy," said Dr. Moses-Kolko, who also is on staff with the Women's Behavioral HealthCARE program of the Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center. "Late exposure was associated with increased risk for a range of complications including jitteriness, stiffened muscle tone, irritability, respiratory distress and feeding problems."
While most cases of neonatal behavioral syndrome are mild and generally resolve in about two weeks, a number are severe enough to require neonatal intensive-care unit (NICU) hospitalization.
"Newborns exposed to antidepressants late in pregnancy had more than twice the risk of admission to a special-care nursery as those exposed only early in pregnancy," Dr. Moses-Kolko said, adding that late-exposed newborns also had twice the risk of respiratory complications some critical. "Respiratory distress ranged from congestion and rapid breathing to extreme danger requiring oxygen therapy and even mechanical ventilation," she said. "A severe syndrome with dehydration, mechanical ventilaPage: 1 2 3 Related biology news :1
. Endogenous cannabinoids linked to fetal brain damage imposed by maternal cannabis use2
. A few more minutes of maternal attachment may reduce anemia in children3
. Childrens Hospital Oaklands new maternal diet study4
. Childrens Hospital and Research Center-Oakland presents a new maternal diet study5
. Call for global action over continued huge burden of maternal deaths in poor countries6
. Preconception care crucial to improving maternal and infant health7
. Zebra finch males prefer females with exaggerated maternal traits8
. Infant bone growth and maternal vitamin D levels during pregnancy influence future fracture risk9
. Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers10
. ASU researchers find link between social behavior, maternal traits in bees11
. Ingestion of afterbirth appears to promote maternal behavior in mammals