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Mapping system tells skin cells whether to become scalp, palm tissues, Stanford study finds

om the top half of the body - arms, head and chest, for example - shared expression patterns that were markedly different from the patterns shared among cells from the bottom part of the body, such as the legs and feet. Similar patterns existed among cells originating close to or far from the center of the body, and those from the outer or the inner layer of the skin.

While these three rough anatomical divisions don't provide the precise coordinates of a global-positioning system, they do help explain similarities between the skin on the palms of the hands and the relatively distant soles of the feet. Like botanically similar areas of the world that share a latitude and altitude but differ in longitude, both the palms and soles are on the outer layer of the skin far from the center of the body and are more like one another than like their biological neighbors.

"Ideally, we can use this finding to develop a positional map that will allow us to correlate location with function in a way that will make it easier to regenerate certain parts of the body," said Rinn. "For example, if we need to grow skin in the laboratory to graft onto someone with badly burned palms, we'll know how to turn on the specific genes that make that type of skin." The implications are vast. Fibroblasts and other skin cells also comprise the lining of the lung and intestine as well as internal organs.

Not every kind of skin cell expresses gene patterns that can be correlated with their location in the body; the study found no such association in endothelial cells, which might depend on signals from surrounding cells.

"It's not like every cell has this code," said Rinn. "I like to think of the fibroblasts as wise, old parental cells who may tell the others how to behave." Their input is invaluable during embryogenesis, normal growth and wound healing, each of which requires location-specific responses by cells. Many of the genes identified by Rinn are known
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Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
2-Aug-2006


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