HOME >> BIOLOGY >> NEWS
Mapping the protein world

In the early days of X-ray crystallography obtaining a three-dimensional model of a protein required wire models, screws, bolts and years of tedious calculations by hand. Today macromolecular models are built by computers thanks to sophisticated software and in particular a package called ARP/wARP. Developed by Victor Lamzin at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and Anastassis Perrakis at the Netherlands Cancer Institute (NKI) in Amsterdam, ARP/wARP is currently used by over 2,000 researchers throughout the world. The capabilities of this software will now expand even further - thanks to a grant of over 800,000 US Dollars from the U.S. National Institutes of Health (NIH).

The grant, which will run over four years, comes at a perfect time. "More than 1,000 research laboratories from over 50 countries are holding ARP/wARP licenses and by June this year our paper that described the key innovative feature of ARP/wARP in Nature Structural Biology in 1999 has reached the magic number of 1,000 citations in the scientific literature. This has created an incredible drive for further scientific development," Lamzin says. "The new funding gives us a push to advance the software's ability to recognise and distinguish different types of macromolecular objects, for example DNA, and to improve the automated generation of structural models. ARP/wARP has made the life of structural biologists worldwide a lot easier and will do even more so once the new features planned under the NIH grant have been implemented."

ARP/wARP transforms 'electron density maps', produced in experiments that bombard protein crystals with X-rays, into 3-dimensional structures. "X-ray experiments result in 'diffraction patterns' that can't be interpreted using our eyes," Lamzin says. "These have to be reconstructed into a three-dimensional image through mathematics and models. This was a very tedious, time-consuming, and subjective process."

ARP
'"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
0049-622-138-7452
European Molecular Biology Laboratory
11-Jul-2006


Page: 1 2

Related biology news :

1. Mapping the mouse genome
2. Cassinis Visual and Infrared Mapping Spectrometer detects vast polar ethane cloud on Titan
3. Mapping system tells skin cells whether to become scalp, palm tissues, Stanford study finds
4. Mapping the foundation of human development
5. Mapping dynamic Polycomb group proteins during Drosophila development
6. Mapping neuron connections in the brain
7. Organization for Human Brain Mappings 11th Annual Meeting
8. Mapping the underwater world in 3-D
9. Penn researchers discover how key protein stops inflammation
10. UCF research links proteins, stem cells and potential Alzheimers treatment
11. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... (PRWEB) , ... September 05, 2018 , ... ... Platform for a mAb manufacturing facility late last year, IPS-Integrated Project Services, LLC ... the manufacturing of autologous cell therapies. The iCON solution provides a pre-fabricated modular ...
(Date:8/31/2018)... ... August 30, 2018 , ... R3 Stem Cell, the ... for new clients. The freezers are very convenient for practices to maintain regenerative ... consist of amniotic and umbilical cord tissue. They are stored at -80 degrees ...
(Date:8/31/2018)... ... August 30, 2018 , ... USDM Life Sciences , the ... and healthcare industries, has received the 2018 Services Partner of the Year, Awarded for ... Box SVP of Business Development and Platform Sales, Niall Wall and received by USDM ...
Breaking Biology News(10 mins):
(Date:9/12/2018)... ... September 11, 2018 , ... ... add flat sheet Forward Osmosis (FO) membranes from Fluid Technology Solutions (FTS H2O) ... by FTS H2O are constructed from cellulose triacetate (CTA) material. The highly hydrophilic ...
(Date:9/7/2018)... ... September 06, 2018 , ... The Discovery on ... meeting of “The industry’s preeminent event on novel drug targets.” BellBrook Labs’ high ... to study these emerging targets in a quest to find new treatments for ...
(Date:9/7/2018)... ... September 06, 2018 , ... Akadeum Life Sciences today announced it has ... an executive and leader of numerous biotech companies. , He most recently served ... acquired by Thompson Street Capital in St. Louis, MO. Prior to ISTO, he ...
(Date:8/31/2018)... ... August 30, 2018 , ... Small, wireless and networked describes more than ... getting connected, too. Draper’s latest system is tiny in size, but is poised to ... factor in the new implant design is the growing awareness that disease often involves ...
Breaking Biology Technology:
Cached News: