HOME >> BIOLOGY >> NEWS
Marine moss reveals clues to anticancer compound

PORTLAND, Ore. - An Oregon Health & Science University researcher believes the discovery of a gene cluster from a bacterium that protects a moss-like marine invertebrate from predators may be the first step toward engineering cancer-fighting drugs.

Margo Haygood, Ph.D., professor of environmental and biomolecular systems at OHSU's OGI School of Science & Engineering, has detailed her research team's discovery of the large gene cluster in a bacterium that protects the larvae of the bushy marine bryozoan Bugula neritina.

The bacterium, Endobugula sertula, acting as a symbiont to its bryozoan host, secretes a bioactive molecule that makes the poppy seed-sized larvae distasteful to predatory fish. But that molecule, known as a bryostatin, also confounds a variety of cancer cell lines.

"The larvae are covered with a skin of bryostatins," said Haygood, whose research was described recently in the Journal of Natural Products. "They need this kind of protection. We also discovered there are bryostatins on the root structures of the adults, perhaps to help them maintain their territory. But their main function is protecting the larvae."

And, it turns out, protecting people. Scientists have long known bryostatins, particularly a type of the compound called bryostatin 1, have anti-cancer properties, including activity against pancreatic and renal cancer, leukemia, non-Hodgkin's lymphoma and melanoma that involves flipping a switch that makes the cancer cells behave like normal cells. Bryostatin 1 is even in phase I and II clinical trials alone and in combination with other drugs.

But the problem has been getting the bryostatins in the large quantities needed for pharmaceutical development. Culturing the bacteria, for example, is challenging because the organism doesn't adapt well to conditions outside the narrow range provided by the host bryozoan. In addition, aquaculture of the bryozoan to produce the compounds is
'"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
8-Mar-2007


Page: 1 2

Related biology news :

1. Census of Marine Life historians detail collapse of bluefin tuna population off northern Europe
2. Marine worm opens new window on early cell development
3. Marine phytoplankton changes form to protect itself from different predators
4. German-Korean collaboration in Polar and Marine research will be intensified
5. Marine reserves could save coral reefs
6. Marine scientists monitor longest mammal migration
7. Elsevier launches new journal, Marine Genomics
8. Climate changes brews trouble for marine life in European Seas, Marine Board-ESF report says
9. Science for long-term management of the Marine Life Protection Act
10. Marine life stirs ocean enough to affect climate, says FSU study
11. Coral reef conservation by means of the global network of Marine Protected Areas

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2017)... , Feb. 2, 2017   TapImmune, Inc. ... immuno-oncology company specializing in the development of innovative ... treatment of cancer and metastatic disease, announced today ... GMP manufacturing of a second clinical lot of ... folate receptor alpha. The manufactured vaccine product will ...
(Date:1/30/2017)... , Jan. 30, 2017   Invitae Corporation ... growing genetic information companies, today announced that it will ... and provide 2017 guidance on Monday, February 13, 2017, ... that day at 4:45 p.m. Eastern / 1:45 p.m. ... team will briefly review financial results, guidance, and recent ...
(Date:1/24/2017)...  It sounds simple and harmless—an electronic sensor ... signs and alerts parents on their smart phones ... drops. But pediatric experts argue that such devices ... evidence of medical benefits, especially to healthy babies. ... parents of healthy babies, promising peace of mind ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... SAN DIEGO and SAN FRANCISCO ... , a privately-held regenerative medicine company, and Beyond Type ... living with type 1 diabetes, today announced a grant ... develop a functional cure for type 1 and other ... decade, ViaCyte has been developing innovative stem cell-derived cell ...
(Date:2/22/2017)... ... 22, 2017 , ... Kernel , a human intelligence ... (KRS) clinical development program. KRS is a neurotechnology spin-out from the Massachusetts ... applications. The terms of the transaction were not disclosed. , It addition ...
(Date:2/22/2017)... Feb. 22, 2017 Scientists propose in ... organ damage in Gaucher and maybe other lysosomal storage ... lower costs than current therapies. An international ... Center , which also included investigators from the University ... their data Feb. 22. The study was conducted in ...
(Date:2/22/2017)... ... February 22, 2017 , ... LabRoots ... scientists from around the world, is pleased to announce the 2nd annual Precision ... 2017. This premier, online-only conference focused on the development and advancements in precision ...
Breaking Biology Technology:
Cached News: