HOME >> BIOLOGY >> NEWS
Marine moss reveals clues to anticancer compound

PORTLAND, Ore. - An Oregon Health & Science University researcher believes the discovery of a gene cluster from a bacterium that protects a moss-like marine invertebrate from predators may be the first step toward engineering cancer-fighting drugs.

Margo Haygood, Ph.D., professor of environmental and biomolecular systems at OHSU's OGI School of Science & Engineering, has detailed her research team's discovery of the large gene cluster in a bacterium that protects the larvae of the bushy marine bryozoan Bugula neritina.

The bacterium, Endobugula sertula, acting as a symbiont to its bryozoan host, secretes a bioactive molecule that makes the poppy seed-sized larvae distasteful to predatory fish. But that molecule, known as a bryostatin, also confounds a variety of cancer cell lines.

"The larvae are covered with a skin of bryostatins," said Haygood, whose research was described recently in the Journal of Natural Products. "They need this kind of protection. We also discovered there are bryostatins on the root structures of the adults, perhaps to help them maintain their territory. But their main function is protecting the larvae."

And, it turns out, protecting people. Scientists have long known bryostatins, particularly a type of the compound called bryostatin 1, have anti-cancer properties, including activity against pancreatic and renal cancer, leukemia, non-Hodgkin's lymphoma and melanoma that involves flipping a switch that makes the cancer cells behave like normal cells. Bryostatin 1 is even in phase I and II clinical trials alone and in combination with other drugs.

But the problem has been getting the bryostatins in the large quantities needed for pharmaceutical development. Culturing the bacteria, for example, is challenging because the organism doesn't adapt well to conditions outside the narrow range provided by the host bryozoan. In addition, aquaculture of the bryozoan to produce the compounds is
'"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
8-Mar-2007


Page: 1 2

Related biology news :

1. Census of Marine Life historians detail collapse of bluefin tuna population off northern Europe
2. Marine worm opens new window on early cell development
3. Marine phytoplankton changes form to protect itself from different predators
4. German-Korean collaboration in Polar and Marine research will be intensified
5. Marine reserves could save coral reefs
6. Marine scientists monitor longest mammal migration
7. Elsevier launches new journal, Marine Genomics
8. Climate changes brews trouble for marine life in European Seas, Marine Board-ESF report says
9. Science for long-term management of the Marine Life Protection Act
10. Marine life stirs ocean enough to affect climate, says FSU study
11. Coral reef conservation by means of the global network of Marine Protected Areas

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Marine moss reveals clues anticancer compound

(Date:5/22/2015)... , May 22, 2015 According ... by Solution (2D, 3D, Thermal, Emotion, Forensic), by Software (Middleware, ... (Government and Utilities, Consumer and Home) - Global Forecast ... grow from $2.77 Billion in 2015 to $6.19 Billion ... Browse 79 market data Tables and   43 ...
(Date:5/19/2015)... 18, 2015 Fingerprint Cards (FPC) has ... FPC1145, FPC1155 and FPC1035 from one if its module partners. ... including Q3 2015 and the sensors will be used by ... values for 2015 hereby amount to 740 MSEK to date. ... 140 MSEK and a number of smaller orders not separately ...
(Date:5/14/2015)... YORK , May 14, 2015 /PRNewswire/ ... in identity verification and online remote proctoring, ... a software-as-a-service (SaaS) company and creator of ... customers of the two companies will benefit ... in Canvas. As a fully ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2
(Date:5/28/2015)... May 28, 2015 Biscayne Pharmaceuticals, Inc ... of its growth hormone-releasing hormone (GHRH) technology will be discussed ... ASCO Annual Meeting. The data show that the family ... GHRH blockers, is present on many primary breast cancer ... that GHRH antagonists could have broad anti-cancer potential in ...
(Date:5/28/2015)... Glenn Keet, CEO of Clinovo ... EMR/EHR Clinical Data Integration with EDC Systems ” at ... DC on June 14th-18th. , During the presentation, Glenn ... with EDC, and will examine the value of patient ... electronic health records/electronic medical records integration. , The ...
(Date:5/28/2015)... May 28, 2015 Dr. Carl ... today that Roger L. Williams, MD, has joined ... Partners Premier Experts are top tier consultants whose ... extraordinary value to the company’s clients. Premier Experts ... help clients successfully develop their medical products, pursue ...
(Date:5/27/2015)... RXi Pharmaceuticals Corporation (NASDAQ: RXII ... developing innovative therapies primarily in the areas of ... a public offering of shares of its common ... stock and overallotment purchase rights to purchase shares ... stock, warrants and overallotment purchase rights are immediately ...
Breaking Biology Technology:Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 2Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 3Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2Former CEO and Chair of the Council of Experts at the USP, Roger L. Williams, MD, Joins NDA Partners as a Premier Expert Consultant 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3
Cached News: