HOME >> BIOLOGY >> NEWS
Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds

A team of researchers, led by surgeons at the Kimmel Cancer Center at Jefferson in Philadelphia, has found further evidence supporting the ability of a protein to predict how well a patient with advanced pancreatic cancer will do after surgery, chemotherapy and radiation. The levels of the protein CA 19-9 in the blood can be used to determine the need for further therapy, they say.

Adam Berger, M.D., assistant professor of surgery at Jefferson Medical College of Thomas Jefferson University, and his co-workers examined CA 19-9 levels and the survival of 385 patients with advanced pancreatic cancer who were treated with surgery and subsequent chemotherapy and radiation. They found that those patients whose post-operative CA 19-9 level exceeded 180 U/ml did much worse than those with lower levels.

In fact, at least half of those whose CA 19-9 level was higher than 180 U/ml lived for approximately nine months, while half of those whose levels were 180 or below lived more than twice as long, about 21 months. After three years, about 30 percent of those with levels 180 or under were still alive, while virtually none of the patients with levels above 180 remained alive. He reports his teams findings June 23, 2007 at the semi-annual meeting of the Radiation Therapy Oncology Group (RTOG) in Philadelphia.

We think that it is a very sensitive predictor of response to chemotherapy and radiation after surgery, says Dr. Berger.

The main goal of the multicenter trial was to compare pancreatic cancer surgery patients who received two different types of chemotherapy 5FU or gemcitabine along with radiation. It was designed to look at CA 19-9 levels and survival after surgery as a secondary goal. Patients submitted blood samples prior to chemotherapy, which were analyzed for CA 19-9. Overall, 385 patients had levels that could be analyzed.

According to Dr. Berger, a post-surgery CA 19-9 level of 180 or less translated to a 72
'"/>

Contact: Steven Benowitz
Steven.Benowitz@jefferson.edu
215-955-6300
Thomas Jefferson University
22-Jun-2007


Page: 1 2

Related biology news :

1. Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers
2. Markers found for bacterial vaginosis
3. Markers of brain cell development may help success of stem cell transplants
4. Gene predicts better outcome as cortex normalizes in teens with ADHD
5. Major study predicts grim future for Europes seas
6. FDG-PET imaging clearly predicts lung cancer patients response to chemotherapy
7. NASA predicts nongreen plants on other planets
8. Gene profiling predicts resistance to breast cancer drug Herceptin
9. Mathematical model predicts cholera outbreaks
10. New test predicts blood cancers sensitivity to experimental cancer drug
11. Blood test predicts cardiac events and death in heart patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Firmex ... solution that makes it easy for organizations to send and gather large files ... FTP software or email file size limitations. , Using the same market-tested ...
(Date:5/23/2017)... ... May 22, 2017 , ... A new Technology Hot ... California, this August will feature high-level speakers on quantum devices, graphene electronic tattoo ... and Photonics, the largest multidisciplinary optical sciences meeting in North America, will run ...
(Date:5/23/2017)... ... ... Cambridge Semantics , the leading provider of Big Data management and ... Expo in Boston May 23-25 with a featured speaker and solution demos of ... is also a finalist for the Best of Show award. , James LaPointe, Managing ...
(Date:5/21/2017)... LOS ANGELES, CA (PRWEB) , ... May 19, ... ... at the annual meeting and educational conference of the American Association of Bioanalysts ... at the Galleria Hotel in Houston. The conference reinforces AAB’s commitment to excellence ...
Breaking Biology Technology:
Cached News: