HOME >> BIOLOGY >> NEWS
Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds

A team of researchers, led by surgeons at the Kimmel Cancer Center at Jefferson in Philadelphia, has found further evidence supporting the ability of a protein to predict how well a patient with advanced pancreatic cancer will do after surgery, chemotherapy and radiation. The levels of the protein CA 19-9 in the blood can be used to determine the need for further therapy, they say.

Adam Berger, M.D., assistant professor of surgery at Jefferson Medical College of Thomas Jefferson University, and his co-workers examined CA 19-9 levels and the survival of 385 patients with advanced pancreatic cancer who were treated with surgery and subsequent chemotherapy and radiation. They found that those patients whose post-operative CA 19-9 level exceeded 180 U/ml did much worse than those with lower levels.

In fact, at least half of those whose CA 19-9 level was higher than 180 U/ml lived for approximately nine months, while half of those whose levels were 180 or below lived more than twice as long, about 21 months. After three years, about 30 percent of those with levels 180 or under were still alive, while virtually none of the patients with levels above 180 remained alive. He reports his teams findings June 23, 2007 at the semi-annual meeting of the Radiation Therapy Oncology Group (RTOG) in Philadelphia.

We think that it is a very sensitive predictor of response to chemotherapy and radiation after surgery, says Dr. Berger.

The main goal of the multicenter trial was to compare pancreatic cancer surgery patients who received two different types of chemotherapy 5FU or gemcitabine along with radiation. It was designed to look at CA 19-9 levels and survival after surgery as a secondary goal. Patients submitted blood samples prior to chemotherapy, which were analyzed for CA 19-9. Overall, 385 patients had levels that could be analyzed.

According to Dr. Berger, a post-surgery CA 19-9 level of 180 or less translated to a 72
'"/>

Contact: Steven Benowitz
Steven.Benowitz@jefferson.edu
215-955-6300
Thomas Jefferson University
22-Jun-2007


Page: 1 2

Related biology news :

1. Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers
2. Markers found for bacterial vaginosis
3. Markers of brain cell development may help success of stem cell transplants
4. Gene predicts better outcome as cortex normalizes in teens with ADHD
5. Major study predicts grim future for Europes seas
6. FDG-PET imaging clearly predicts lung cancer patients response to chemotherapy
7. NASA predicts nongreen plants on other planets
8. Gene profiling predicts resistance to breast cancer drug Herceptin
9. Mathematical model predicts cholera outbreaks
10. New test predicts blood cancers sensitivity to experimental cancer drug
11. Blood test predicts cardiac events and death in heart patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
(Date:3/24/2017)... DUBLIN , Mar 24, 2017 Research ... Vehicle Access System Market Analysis & Trends - Industry Forecast to ... ... poised to grow at a CAGR of around 15.1% over the ... This industry report analyzes the market estimates and forecasts for ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... -- The National Pharmaceutical Council (NPC) today announced that Ipsen ... as its newest member. David Cox , PhD, ... America ), will serve as his company,s representative ... to have Ipsen and Dr. Cox join NPC as ... welcome their insights in helping us identify and address ...
(Date:3/28/2017)... March 28, 2017  Viking Therapeutics, Inc. ("Viking") (NASDAQ: ... of novel therapies for metabolic and endocrine disorders, today ... , Ph.D., will deliver a corporate presentation at H.C. ... Conference, being held April 3, 2017 at the St. ... for this presentation are as follows: ...
(Date:3/28/2017)... 28, 2017 Dr. Chris Yu ... corporation Anpac Bio-Medical Science Company , announced ... record, processing and reporting over 40,000 cases worldwide ... (CDA) liquid biopsy tests. Described ... Summit publications, Anpac Bio,s CDA medical devices and ...
(Date:3/28/2017)... , March 28, 2017 Biostage, Inc. ... company developing bioengineered organ implants to treat cancers and ... today announced that Jim McGorry, CEO of ... BioEngineering panel at the MassBio 2017 Annual ... PM ET in Cambrige, Massachussetts. The 3D Printing ...
Breaking Biology Technology:
Cached News: