Marshfield Clinic researchers launch study of environmental causes of Alzheimer's disease

MARSHFIELD, Wis. -- Marshfield Clinic researchers have begun searching for genetic and environmental links to Alzheimer's disease as a first step toward developing diagnostic markers to identify people at risk before they develop the disease.

Researchers will study the DNA of Alzheimer's patients from its database of more than 18,000 voluntarily-donated DNA samples. The Marshfield Clinic Research Foundation (MCRF) created the database as part of its landmark Personalized Medicine Research Project (PMRP).* Marshfield Clinic also has a complete electronic medical record on each of the individuals to be studied.

"We know exactly the medication they have been taking and what diseases they have been diagnosed for. We also know some environmental factors," said Principal Investigator Nader Ghebranious, Ph.D., director of the Molecular Diagnostics Laboratory, Marshfield Laboratories. "Now we can do genetic analysis and examine the DNA together with phenotypes and relevant environmental factors."

"It's exciting because we're not looking at just environmental risk factors, or just genetics, but the two together," said Marshfield Clinic Epidemiologist Catherine McCarty, Ph.D., principal investigator of the Personalized Medicine Research Project and co-investigator of the Alzheimer's study. "We are the first that I know of to look at the interaction between genetics and environment on the risk of disease." The study requires 150 people with Alzheimer's disease and about 300 people of similar age who do not have the disease. "Association studies like this require us to match people who have the illness with those who do not," Ghebranious said.

Because the disease is extremely complex, researchers believe that more than one genetic anomaly and perhaps environmental factor leads to Alzheimer's disease. Marshfield Clinic researchers are studying four specific genes and their connection to the disease process.

"It is important to consider more than o

Contact: Chris Schellpfeffer
Marshfield Clinic

Page: 1 2 3

Related biology news :

1. Marshfield Clinics electronic health record first to receive CCHIT certification
2. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
3. Scientists honored with Excellence in Clinical Research Award
4. Clinical trial data regarding NKTR-061 will be presented at ATS International Conference
5. NIH awards VBI, Mayo Clinic $2.4M to study chronic rhinosinusitis
6. Clinical trial for diabetic macular edema
7. The Parkinsons Institute to conduct Phase III Clinical Trial of creatine for Parkinsons disease
8. Research and program highlights of the 2007 Annual Clinical Genetics Meeting, March 21-25, 2007
9. Arizona State University and Mayo Clinic join forces to develop cancer vaccine
10. American College of Medical Genetics -- 2007 Annual Clinical Genetics Meeting Announcement
11. October MCP: A special issue on Clinical Proteomics

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: