HOME >> BIOLOGY >> NEWS
Massive gene screening points way to more effective chemotherapy

DALLAS April 11, 2007 -- Using a technology that can quickly screen all 20,000-plus human genes for biological activity, scientists have isolated 87 genes that seem to affect how sensitive human cancer cells are to certain chemotherapy drugs.

In a study available online and appearing in the April 12 edition of the journal Nature, researchers at UT Southwestern Medical Center describe how they used a library of small RNA molecules the first used by a university research center to identify the genes.

When the researchers blocked the action of some of the 87 genes inside isolated lung-cancer cells, they found that those cells were up to 10,000 times more sensitive to the chemotherapy drug paclitaxel (Taxol).

The results are important because the ability to lower the dose of chemotherapy drugs without compromising effectiveness reduces debilitating side effects, said Dr. Michael White, professor of cell biology at UT Southwestern, associate director for basic science at the Simmons Comprehensive Cancer Center, and senior author of the study.

"Chemotherapy is a very blunt instrument," he said. "It makes people sick, and its effects are very inconsistent. Identifying genes that make chemotherapy drugs more potent at lower doses is a first step toward alleviating these effects in patients."

The current study tested only isolated cancer cells, so further studies will be needed to determine whether blocking the genes in living animals has the same effect.

The findings were made possible because of a technology that allows scientists to rapidly test how cells react when a given gene is turned off, or "silenced." The so-called high-throughput employs a series of small plastic dishes, each with 96 wells. Using a robot, researchers place small bits of RNA that can block the function of one gene into each well on the plate. Next, non-small-cell lung cancer cells are placed in each well with the RNA.


'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
11-Apr-2007


Page: 1 2

Related biology news :

1. Massive herds of animals found to still exist in Southern Sudan
2. Massive coral death atrributed to earthquake
3. Massive coral death attributed to earthquake
4. Massive duplication of genes may solve Darwins abominable mystery about flowering plants
5. Massive marsh planting to begin in coastal Alabama and Mississippi
6. ACMG recognizes progress made in newborn screening
7. Nearly 90 percent of babies receive recommended newborn screening tests
8. Pre-implantation genetic screening reduces both ongoing pregnancy and live birth rates in over 35s
9. Changes in chromosomal constitution of preimplantation embryos suggest caution in genetic screening
10. Noninvasive screening in early pregnancy reduces Downs births by 50 percent
11. New screening method to help find better biofuel crops

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Firmex ... solution that makes it easy for organizations to send and gather large files ... FTP software or email file size limitations. , Using the same market-tested ...
(Date:5/23/2017)... ... May 22, 2017 , ... A new Technology Hot ... California, this August will feature high-level speakers on quantum devices, graphene electronic tattoo ... and Photonics, the largest multidisciplinary optical sciences meeting in North America, will run ...
(Date:5/23/2017)... ... ... Cambridge Semantics , the leading provider of Big Data management and ... Expo in Boston May 23-25 with a featured speaker and solution demos of ... is also a finalist for the Best of Show award. , James LaPointe, Managing ...
(Date:5/21/2017)... LOS ANGELES, CA (PRWEB) , ... May 19, ... ... at the annual meeting and educational conference of the American Association of Bioanalysts ... at the Galleria Hotel in Houston. The conference reinforces AAB’s commitment to excellence ...
Breaking Biology Technology:
Cached News: