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Mayo researchers define celecoxib pathways and mechanisms for tumor reduction

ds to the reduction in primary breast tumor mass."

She noted that in an experiment with a limited number of mice, celecoxib appeared to completely inhibit metastasis of the breast tumor.

The study employed a mouse model system that closely resembles spontaneous breast cancer progression and metastasis in humans.

"The MTag mouse model for human metastatic breast cancer is a helpful and important model in which to evaluate therapeutic strategies and to understand the mechanisms associated with therapy-induced growth inhibition," said Mukherjee. "This model allows us to proceed with preclinical studies that must precede clinical trials in order to enable us to develop efficient therapeutic strategies with targeted molecular therapies."

Contributing to this report along with Mukherjee were Mayo Clinic cancer researchers Gargi Basu, Ph.D., the lead author on the paper; as well as Sandra Gendler, Ph.D.; Latha Pathangey; M.S.,Teresa Tinder, B.S.; and Michelle LaGioia.


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Contact: Russell Vanderboom, Ph.D.
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
5-Nov-2004


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