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McBride shows DNA detective work with paper-eating bacteria that 'glide'

of the cell.

These filaments were recently imaged in collaboration with Sriram Subramaniam and Jun Liu at the National Institutes of Health by cryo-electron tomography.

"The filaments may be the cell's 'tires,' and there are different kinds," McBride says. "They are designed to help the organism move over a variety of surfaces, like an all-terrain vehicle."

Besides providing movement, McBride says the filaments also may be needed to move the cellulose and chitin molecules to certain sites where they can be digested or taken into the cell.

McBride hopes the complete genome for C. hutchinsonii will yield other clues to the interconnections among gliding bacteria. He is now collaborating with DOE to sequence the entire genome of F. johnsoniae, which will allow a full comparison of the genes of the two microorganisms.


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Contact: Mark McBride
mcbride@uwm.edu
414-229-5844
University of Wisconsin - Milwaukee
2-Jan-2007


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