HOME >> BIOLOGY >> NEWS
Mechanism proposed for link between RU-486 and fatal infections

The abortion drug mifepristone (Mifeprex,TM RU-486) has been linked to rare cases of fatal bacterial infections, but until now the connection has not been clearly understood. In "Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii," author and Brown University professor Ralph P. Miech, MD, PhD, proposes two models of how this devastating reaction may occur. The article appears in The Annals of Pharmacotherapy Online and in the journal's upcoming September print issue.

During an abortion, mifepristone works by blocking the effects of progesterone, shutting off nutrition to the placenta and fetus. However, Miech points out, the antiprogesterone effects of mifepristone also cause changes in the cervix that allow C. sordellii, a common vaginal bacteria, to enter the cervical canal. C. sordellii thrives in this low-oxygen environment and derives nutrition from the decaying fetal tissue. Meanwhile, other hormonal effects of mifepristone, known as antiglucocorticoid actions, are taking place throughout the body. Through two models proposed by Miech, these antiglucocorticoid effects may interfere with chemical regulators known as cytokines, offsetting the delicate balance between over- and under-activation of the immune system. This disruption impairs the body's ability to fight off C. sordellii and may help spread the bacteria's toxic by-products, a combination that sometimes results in widespread septic shock.

At least 5 women in the US and Canada have died from septic shock after taking mifepristone. C. sordellii has been linked to 3 of those cases, while the bacteria remains unidentified in the others. C. sordellii infections are rare outside of mifepristone use and have proven particularly dangerous because they often lack the usual warning signs, such as fever and tenderness on examination.

In 2004, the labeling of mifepristone was amended to include a black box warning about bacterial infections, sepsis
'"/>

Contact: Stanley J. Lloyd, Pharm.D.
AssistEd@theannals.com
Annals of Pharmacotherapy
27-Jul-2005


Page: 1 2

Related biology news :

1. Mechanism of microRNAs deciphered
2. Mechanisms involved with tumor relapse identified
3. Mechanism to organize nervous system conserved in evolution
4. Mechanism for memory revealed in neurons of electric fish
5. Mechanism for Epstein-Barr virus proteins role in blood cancers discovered
6. Mechanism of new sudden-death arrhythmia detailed
7. Mechanism regulating tooth shape formulation found
8. Mechanism for the captation of nutrients in plants- unknown to date
9. Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
10. Telemedicine initiative for sub-Saharan Africa: Pilot projects proposed
11. Major initiative proposed to address amphibian crisis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC ... services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ... patients with severe COVID-19. This is the first study of an XPO1 inhibitor ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, a ... UK supplier and manufacturer of innovative portable renewable energy equipment, have announced the ... against the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable ...
(Date:6/23/2020)... THE WOODLNDS, Texas (PRWEB) , ... June 23, ... ... in X-ray analytical instrumentation, is pleased to announce the next event in a ... of X-ray scattering. , The TOPIQ series of webinars was developed in response ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet ... , Known as MediVet Biologics since its formation in 2016, the ... new Ardent Animal Health will build on its base of innovative therapies for osteoarthritis ...
(Date:7/31/2020)... CAMBRIDGE, Mass. and SOMERSET, N.J (PRWEB) , ... ... ... a leading genome editing company, and Catalent, the leading global provider of advanced ... and consumer health products, today announced that they have entered into a strategic ...
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter maintenance ... a successful study, while protecting and accessing the catheter or device post-surgery is often ... Envigo in a live webinar on Wednesday, August 5, 2020 ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... that Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license ... to move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 ...
Breaking Biology Technology:
Cached News: