HOME >> BIOLOGY >> NEWS
Metabolic syndrome -- don't blame the belly fat

n both insulin resistant and insulin sensitive human subjects.

The subjects for the study were all young, lean, non-smoking, healthy individuals who were sedentary and matched for physical activity. Aside from insulin resistance in one cohort, these volunteers had none of the other confounding factors typically associated with obesity and type 2 diabetes, which have been thought to play a key role in the pathogenesis of the metabolic syndrome.

"Our hypothesis was that the metabolic syndrome is really a problem with how we store energy from food, Shulman explained. "The idea is that insulin resistance in muscle changes the pattern of energy storage."

After providing the study's subjects with two meals high in carbohydrates, Shulman and his colleagues turned to magnetic resonance spectroscopy to measure the production of liver and muscle triglyceride, the storage form of fat, and of glycogen, the storage form of carbohydrate. "What we found is that (insulin) sensitive individuals took the energy from carbohydrate in the meals and stored it away as glycogen in both liver and muscle," said Shulman.

In the insulin resistant subjects, the energy obtained from their carbohydrate rich meals was rerouted to liver triglyceride production, elevating triglycerides in the blood by as much as 60 percent and lowering HDL cholesterol (the good cholesterol) by 20 percent. "In contrast to the young, lean, insulin-sensitive subjects, who stored most of their ingested energy as liver and muscle glycogen, the young, lean, insulin-resistant subjects had a marked defect in muscle glycogen synthesis and diverted much more of their ingested carbohydrate into liver fat production, Shulman and his colleagues reported.

"What we see," he noted, "is alterations in patterns of energy storage. An additional key point is that the insulin resistance, in these young, lean, insulin resistant individuals, was independent of abdominal obesity and circulating plasma adi
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
16-Jul-2007


Page: 1 2 3

Related biology news :

1. Metabolic disorder underlies Huntingtons disease
2. Metabolic Engineering VI
3. Unknotting DNA clue to cancer syndrome
4. Researchers identify fifth gene responsible for Joubert syndrome
5. Fragile X syndrome -- A stimulating environment restores neuronal function in mice
6. Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes
7. U of M researchers find new, more effective treatment for toxic shock syndrome
8. Cherries may help reduce metabolic syndrome and heart disease risk factors
9. Cholesterol could be key to treating fetal alcohol syndrome
10. Rare mutation causes early heart disease and metabolic syndrome
11. Shortening chromosomes cause for earlier cancer onset in families with rare syndrome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2016)... YORK , March 9, 2016 This ... and future states of the RNA Sequencing (RNA Seq) ... segments such as instruments, tools and reagents, data analysis, ... Analyze various segments of the RNA-Sequencing market such as ... services Identify the main factors affecting each segment and ...
(Date:3/8/2016)... , March 8, 2016   Valencell ... technology, today announced it has secured $11M in ... GII Tech, a new venture fund being launched ... additional participation from existing investors TDF Ventures and ... funds to continue its triple-digit growth and accelerate ...
(Date:3/3/2016)... England and DE SOTO, Kansas ... , U.S.-based Stroke Detection Plus® to offer Oncimmune,s ... risk assessment and early detection of lung cancer ... large employers, unions and individuals. --> Early ... unions and individuals. --> Oncimmune, a leader ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... May 04, 2016 , ... Looking for ... San Diego’s premiere hands-on cooking experience. Offering everything from gourmet cooking classes to ... she won’t forget. , Guests that visit LaJollaCooks4u share an experience unlike any ...
(Date:5/4/2016)... 4, 2016 According to a ... Market - Global Industry Analysis, Size, Share, Growth, Trends, ... anticipated to expand at a CAGR of 17.1% from ... 2024. Metabolomics is the extensive study of ... tissues or organisms. Together, these small molecules and their ...
(Date:5/3/2016)... ... 03, 2016 , ... Morf Media Inc ., developer ... on mobile devices, today released a new interactive Food and Drug Administration ... course is essential for owners or operators of places of business that are ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... ... facilitates accessibility to unique bioresearch materials from laboratories across the globe, today announced ... scramble to increase the pace of research toward treatment and prevention measures for ...
Breaking Biology Technology:
Cached News: