HOME >> BIOLOGY >> NEWS
Metabolic syndrome -- don't blame the belly fat

n both insulin resistant and insulin sensitive human subjects.

The subjects for the study were all young, lean, non-smoking, healthy individuals who were sedentary and matched for physical activity. Aside from insulin resistance in one cohort, these volunteers had none of the other confounding factors typically associated with obesity and type 2 diabetes, which have been thought to play a key role in the pathogenesis of the metabolic syndrome.

"Our hypothesis was that the metabolic syndrome is really a problem with how we store energy from food, Shulman explained. "The idea is that insulin resistance in muscle changes the pattern of energy storage."

After providing the study's subjects with two meals high in carbohydrates, Shulman and his colleagues turned to magnetic resonance spectroscopy to measure the production of liver and muscle triglyceride, the storage form of fat, and of glycogen, the storage form of carbohydrate. "What we found is that (insulin) sensitive individuals took the energy from carbohydrate in the meals and stored it away as glycogen in both liver and muscle," said Shulman.

In the insulin resistant subjects, the energy obtained from their carbohydrate rich meals was rerouted to liver triglyceride production, elevating triglycerides in the blood by as much as 60 percent and lowering HDL cholesterol (the good cholesterol) by 20 percent. "In contrast to the young, lean, insulin-sensitive subjects, who stored most of their ingested energy as liver and muscle glycogen, the young, lean, insulin-resistant subjects had a marked defect in muscle glycogen synthesis and diverted much more of their ingested carbohydrate into liver fat production, Shulman and his colleagues reported.

"What we see," he noted, "is alterations in patterns of energy storage. An additional key point is that the insulin resistance, in these young, lean, insulin resistant individuals, was independent of abdominal obesity and circulating plasma adi
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
16-Jul-2007


Page: 1 2 3

Related biology news :

1. Metabolic disorder underlies Huntingtons disease
2. Metabolic Engineering VI
3. Unknotting DNA clue to cancer syndrome
4. Researchers identify fifth gene responsible for Joubert syndrome
5. Fragile X syndrome -- A stimulating environment restores neuronal function in mice
6. Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes
7. U of M researchers find new, more effective treatment for toxic shock syndrome
8. Cherries may help reduce metabolic syndrome and heart disease risk factors
9. Cholesterol could be key to treating fetal alcohol syndrome
10. Rare mutation causes early heart disease and metabolic syndrome
11. Shortening chromosomes cause for earlier cancer onset in families with rare syndrome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... Covalent Metrology has ... Services unit provides high-quality data to clients, both faster and cheaper than ... There are no price premiums, and customers are welcome to participate in the ...
(Date:4/24/2017)... ... April 24, 2017 , ... It ... a cellular milieu; however, the broad application of this cellular target engagement concept ... sensitive quantitative readouts. Cell-based thermal stabilization assays are valuable methods for particular applications, ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... manufactures in 10 categories with over 30 nominees and well as the first-year ... the new award and the event was hosted by CompanyWeek and Manufacturers Edge, ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... ... and Webster Bank, today announced first round funding to three startups through the ... early-stage financial support to new business startups affiliated with UConn. , The UConn ...
Breaking Biology Technology:
Cached News: