HOME >> BIOLOGY >> NEWS
Mice cloned from skin cells

e skin cells, hair follicles, and sebaceous (oil) glands.

Because they reside in the skin, the cells are easily accessible. But purifying and characterizing them has taken years of research. "We had to learn enough about the properties of the different cells within the skin in order to come up with a strategy to isolate pure populations of these cells, and determine that these cells are in fact stem cells," said Fuchs.

In 2004, the group first published a strategy for labeling and monitoring the cells in the journal Science. "Since then, we and others have devised several different ways to isolate these cells, and this has accelerated the rate at which we are learning about the properties and potential of skin stem cells."

To clone the mice, researchers removed the nucleus from an unfertilized egg cell, called an oocyte and replaced it with the nucleus from an adult keratinocyte stem cell. They cultured these hybrid cells in the laboratory to grow them to the blastocyst stage, when the embryo is a tiny hollow ball of cells. At this point, the cultured blastocysts were implanted in a mouse's uterus and allowed to develop into a cloned fetus. This is the cloning technique known as nuclear transfer.

Typically, only about one to two percent of transferred mouse blastocysts result in a live birth. Furthermore, cloned mice that do survive to birth are often not healthy. In Fuchs' and Mombaerts' study, the success rates were 1.6 percent when using skin stem cells from female mice. When the stem cells came from male mice, however, 5.4 percent of the transferred blastocytes developed into mice. The oldest of these animals is now nearly two years, which is old age for a mouse. In addition, many of these mice were fertile and healthy.

The difference in cloning rates of male and female stem cells seems likely to involve epigenetics," Fuchs said. Epigenetic modifications are those that affect a gene's function without altering its DNA se
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
12-Feb-2007


Page: 1 2 3

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. ESF EURYI award winner aims to stop cancer cells reading their own DNA
3. OHSU turns mouse into factory for human liver cells
4. UCLA scientists produce functioning neurons from human embryonic stem cells
5. UCF research links proteins, stem cells and potential Alzheimers treatment
6. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
7. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
8. How cells change the pace of their steps
9. Discredited Korean embryonic stem cells true origins revealed
10. A low expression of MX2 gene exists in the white blood cells of narcoleptics
11. Penn researchers discover pathway that eliminates genetic defects in red blood cells

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mice cloned from skin cells

(Date:12/17/2014)... DENVER , Dec. 16, 2014  Automation ... is this more evident than at international borders. ... secure document scanners have allowed veteran travelers to ... Automated Passport Control (APC) Kiosks at an increasing ... the globe. According to ...
(Date:12/11/2014)... Dec. 10, 2014  Data Sciences International (DSI), ... released a new series of digital telemetry implants ... researchers. M series, part of the PhysioTel™ Digital ... best possible physiologic data when incorporating functional endpoints ... endpoints to toxicology studies has evolved from short ...
(Date:12/10/2014)... DUBLIN , Dec. 08, 2014 Research ... announced the addition of the "Biometrics Market ... http://photos.prnewswire.com/prnh/20130307/600769 ... for projects such as rural banking and upgradation ... major trends witnessed in the market. Besides the ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
(Date:12/17/2014)... AUSTIN, Texas , Dec. 16, 2014  Vermillion, ... company focused on gynecologic disease, today announced the next ... into a premier bio-analytics solutions provider with the naming ... to President and Chief Executive Officer, while current Chairman ... will continue to serve as Chairman. These changes are ...
(Date:12/17/2014)... CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... primary commercial focus on China , ... C meeting with the U.S. Food and Drug Administration ... February 2015.  During this meeting the Company will seek ...
(Date:12/17/2014)...   Synageva BioPharma Corp. (NASDAQ: ... rare disorders, announced today its presentation at the upcoming ... San Francisco, CA. Sanj ... present on Monday, January 12, 2015, at 9:00 a.m. ... live and may be accessed from the "Webcasts & ...
(Date:12/15/2014)... YORK & PETACH TIKVAH, Israel ... Inc. (NASDAQ: BCLI ), a leading developer ... today that wholly-owned subsidiary Brainstorm Cell Therapeutics Ltd. was ... Israel,s Office of the Chief Scientist ... been in receipt of grant support from the Office ...
Breaking Biology Technology:Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3
Cached News: