HOME >> BIOLOGY >> NEWS
Mice cloned from skin cells

e skin cells, hair follicles, and sebaceous (oil) glands.

Because they reside in the skin, the cells are easily accessible. But purifying and characterizing them has taken years of research. "We had to learn enough about the properties of the different cells within the skin in order to come up with a strategy to isolate pure populations of these cells, and determine that these cells are in fact stem cells," said Fuchs.

In 2004, the group first published a strategy for labeling and monitoring the cells in the journal Science. "Since then, we and others have devised several different ways to isolate these cells, and this has accelerated the rate at which we are learning about the properties and potential of skin stem cells."

To clone the mice, researchers removed the nucleus from an unfertilized egg cell, called an oocyte and replaced it with the nucleus from an adult keratinocyte stem cell. They cultured these hybrid cells in the laboratory to grow them to the blastocyst stage, when the embryo is a tiny hollow ball of cells. At this point, the cultured blastocysts were implanted in a mouse's uterus and allowed to develop into a cloned fetus. This is the cloning technique known as nuclear transfer.

Typically, only about one to two percent of transferred mouse blastocysts result in a live birth. Furthermore, cloned mice that do survive to birth are often not healthy. In Fuchs' and Mombaerts' study, the success rates were 1.6 percent when using skin stem cells from female mice. When the stem cells came from male mice, however, 5.4 percent of the transferred blastocytes developed into mice. The oldest of these animals is now nearly two years, which is old age for a mouse. In addition, many of these mice were fertile and healthy.

The difference in cloning rates of male and female stem cells seems likely to involve epigenetics," Fuchs said. Epigenetic modifications are those that affect a gene's function without altering its DNA se
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
12-Feb-2007


Page: 1 2 3

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. ESF EURYI award winner aims to stop cancer cells reading their own DNA
3. OHSU turns mouse into factory for human liver cells
4. UCLA scientists produce functioning neurons from human embryonic stem cells
5. UCF research links proteins, stem cells and potential Alzheimers treatment
6. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
7. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
8. How cells change the pace of their steps
9. Discredited Korean embryonic stem cells true origins revealed
10. A low expression of MX2 gene exists in the white blood cells of narcoleptics
11. Penn researchers discover pathway that eliminates genetic defects in red blood cells

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mice cloned from skin cells

(Date:3/12/2015)... 2015 The mascots of the Atlantic Coast ... of Wake Forest Baptist Medical Center. They stopped by ... ACC Men,s Basketball Tournament. Young patients enjoyed bonding with ... their autographs. Brenner Children,s Hospital is the ... only children,s hospital in northwest North Carolina ...
(Date:3/11/2015)... and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ) has announced ... Product, Application & By Geography - Global Forecast & ... This report predicts that the access control ... with an estimated CAGR of 10.6%. The ... as contact cards & readers, contactless cards & readers, ...
(Date:3/10/2015)... Transforming How We Look at ... in Human Space Flight" by Michael A. ... Ph.D. was recently featured by Springer Science Media, highlighting the ... Specifically, "Personalized Medicine in Human Space Flight" was ... 2013 and 2014 from Springer in the journal ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2
(Date:3/26/2015)... 2015 Neogen Corporation (NASDAQ: NEOG ) ... quarter of fiscal 2015, which ended Feb. 28, increased ... $6,575,000. Earnings per share in the current quarter were ... net income increased 17% over prior year to $24,142,000, ... per share, for the same period a year ago. ...
(Date:3/26/2015)... Ale Gicqueau, Founder and President of Clinovo, will ... Align Technology, on “ Conducting Postmarket Registries - Rationale ... Conference and Exhibition on April 25th through April 28th ... poster presentation, Ale Gicqueau and Victor Chen will discuss ... the requirements and resources to conduct the registry, as ...
(Date:3/25/2015)... /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: ... recent discussions with certain shareholders representing approximately 45% of ... dealing with certain matters including the appointment of auditors ... March 26, 2015 (the "Meeting") it intends to adjourn ... take place when the Meeting reconvenes. The Meeting will ...
(Date:3/25/2015)... Laboratory workers can turn to ... Balances to get best-performing features while still remaining ... from the trusted brand include: , Cole-Parmer ... efficiency by providing a large weighing surface for ... include parts counting, percent weighing, checkweighing, animal/dynamic weighing, ...
Breaking Biology Technology:Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2
Cached News: