The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Mice with defective sperm offer clues to infertility in men

s two areas of the sperm tail. Studying sperm from mice lacking Septin 4 allows us to finally ask if this is really the case, and the findings will advance our understanding of how sperm become cells capable of fertilization."

Research on the roles of both the ARTS and Septin 4 proteins in sperm maturation may further our understanding of male infertility and potentially improve the fertility and quality of sperm in infertile men. Also, these proteins are attractive targets for male contraceptive drugs, because while the sperm are still produced in the mutant mice, they are unable to fertilize an egg.

"There are not many mutations that cause complete sterility without affecting the anatomy of the testis, as with our mouse," says Kissel. "The Septin 4 and ARTS proteins are great targets because interfering with them could accomplish inhibition of fertility without any negative side effects."

"This is a really great starting point," says Steller. "We were originally interested in the cell death aspects of these proteins, but the mouse has opened up many other nice opportunities-including insights into human sterility-that we are currently pursuing."

Contributing authors include Maria Magdalena Georgescu, formerly at Rockefeller and now at the University of Texas M.D. Anderson Cancer Center; Sarit Larisch, a scientist visiting Rockefeller from the Rambam Medical Center in Israel; and Katia Manova at Memorial Sloan-Kettering Cancer Center.


'"/>

Contact: Kristine A. Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
21-Mar-2005


Page: 1 2 3

Related biology news :

1. Study implicates defective synapse generator in onset of Alzheimers
2. UCLA scientists discover new way to fix defective gene
3. Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring
4. First research to show that diabetes damages DNA in mens sperm and may affect fertility
5. Early-stage sperm cells created from human bone marrow
6. Maternal beef diet could impact sperm counts, UR study suggests
7. Link between beef consumption during pregnancy and reduced sperm quality in sons
8. Tracking sperm whales and jumbo squid
9. Rodent sperm work together for better results
10. Single molecular mark seen as pivotal for genome compaction in spores and sperm
11. Chromosomal abnormalities in sperm higher after vasectomy reversal

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mice with defective sperm offer clues infertility men

(Date:11/25/2009)...he Cell Death Research Laboratory in the Universit...ed the prestigious Johnson & Johnson Focused Fundi...rain cell damage in Parkinson,s disease. The award...ort of innovation and excellence in science, was a... this month at an event at the Hyatt Regency Hotel...
(Date:11/25/2009)... the heart pumps some 250 million liters of blood ...cle fibers of the heart have to be extremely durab...bauer, vice chair of the Department of Medicine II...f. Dr. H. A. Katus), has discovered a protein that...muscular unit, the sarcomere. In cooperation with ...
(Date:11/25/2009)... be just as vital to your health as what you eat, ...ical Studies. Their experiments in mice revealed t...nes in the liverthe body,s metabolic clearinghouse... body,s circadian clock as conventional wisdom had... of a large number of genes completely independent...
Breaking Biology News(10 mins):Johnson & Johnson award goes to research of the cause of brain cell damage in Parkinson's 2New genetic cause of cardiac failure discovered 2Feeding the clock 2Feeding the clock 3Cost Effective Solution for Patient Testing 3A Introducing Comprehensive and Affordable Molecular Diagnosis With Verifiable Accuracy 55774 1Cost Effective Solution for Patient Testing 3A Introducing Comprehensive and Affordable Molecular Diagnosis With Verifiable Accuracy 55774 2In Case You Missed It Senator Bob Dole in The Washington Post 3A Starting Over on Health Care 55770 1In Case You Missed It Senator Bob Dole in The Washington Post 3A Starting Over on Health Care 55770 2New Assessment Quantifies Risks and Benefits of Warfarin Treatment for Atrial Fibrillation 4923 1New Assessment Quantifies Risks and Benefits of Warfarin Treatment for Atrial Fibrillation 4923 2New Assessment Quantifies Risks and Benefits of Warfarin Treatment for Atrial Fibrillation 4923 3New Assessment Quantifies Risks and Benefits of Warfarin Treatment for Atrial Fibrillation 4923 4
(Date:11/25/2009)...CytochromatodayannouncedtheappointmentofPeterMoldt...rikSporkastheNovoA/SrepresentativeontheCompany,sBo...mbers. ,, "WeareverypleasedtowelcomePeterMoldtt...ceandguidanceasCytochromacontinuestomakeprogressin...company,"statedAlanLewis,PhD,ChairmanofCytochroma,...
(Date:11/25/2009)...portlinker.comannouncesthatanewmarketresearchrepor...lMarketAnalysisandForecaststo2013 ,, http://w...ket-Analysis-and-Forecasts-to-2013.html ,, Bra..., Summary ,, Thereportprovidesdetailedanalysi...ilbioethanolmarketinparticular.Italsohelpsinanalyz...
(Date:11/24/2009)...n . , Whether it,s CD packaging, containers ...y Identification) are increasingly finding their w...bel objects or goods and identify them automatical... read and process the data contained in the label....tion conditions of up to 100 degrees Celsius. But ...
(Date:11/24/2009)...o also Visit Detroit , (V...French Ambassador for International Investment, an... , , , ,What: Ambassador Appia is available to me...atives adopted by France to further develop the fi...ion and development., , ,When: Available for Inter...
Breaking Biology Technology:Cytochroma Announces Appointment of Peter Moldt to Board of Directors 2Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 2Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 3Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 4Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 5Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 6Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 7Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 8Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 9Intelligence inside metal components 2
Other News:
... crocodile relative excavated last year at Petrifi... into theories of how and where the dinosaurs aros...e Triassic Period.......The animal, one of many cr...ir teeth, was thought to be an ancestor of the pla...
There's more than meets the human ear when the black-capped chickadee lets its flock mates know a predator is lurking about by giving out its familiar "chick-a-dee-dee-dee" call.... The small songbird
.......The disease is triggered off by the bite of an...t the mosquito pumps threadworm larvae into its ho..., where they grow into threadworms which may be up...cing inflammation which halts the flow of lymphati...
... team of U.S. and Canadian scientists has develope...s nonhuman primates from experimental infection wi... published in the online and print editions of the...evelopment of a vaccine for human use. Currently ...
Revueltosaurus skeleton unearthed at Petrified Forest upsets dinosaur tale 2Revueltosaurus skeleton unearthed at Petrified Forest upsets dinosaur tale 3Revueltosaurus skeleton unearthed at Petrified Forest upsets dinosaur tale 4Chickadees' alarm calls carry information about size, threat of predators 2Antibiotics help combat dangerous tropical disease 2Antibiotics help combat dangerous tropical disease 3Experimental vaccine protects nonhuman primates from Lassa fever 2Experimental vaccine protects nonhuman primates from Lassa fever 3
...e best bet for averting the deadly spread of small...ay rest with the establishment of a major collabor...gs that would involve the pharmaceutical and biote...gencies, according to a new report from the Nation...
...ologists at the University of California, San Dieg...s to fight a class of toxins made by a wide variet...y, detailed in this week's early online edition of...es, could eventually pave the way for the developm...
...ople say size doesn't matter, and that may be true...ts that make up the bottom of the marine food-chai...er, and longer term climate, in ways that serve th...new NASA-funded research confirms an old theory th...
... saw it. He heard it. But he needed proof.... ... Daniel Lane was haunted by the memory of an unusu...limpse of it while bird watching in Peru. They eve... it was something new. Something different. ... ...
Report outlines steps needed to lessen smallpox threat 2Report outlines steps needed to lessen smallpox threat 3Report outlines steps needed to lessen smallpox threat 4UCSD biologists discover cell's defense mechanism against class of disease-causing bacterial toxins 2UCSD biologists discover cell's defense mechanism against class of disease-causing bacterial toxins 3UCSD biologists discover cell's defense mechanism against class of disease-causing bacterial toxins 4When sun's too strong, plankton make clouds 2When sun's too strong, plankton make clouds 3When sun's too strong, plankton make clouds 4LSU researcher discovers new bird 2