Micro RNAs play role in egg making

EVANSTON, Ill. --- Researchers at Northwestern University and Carnegie Mellon University have found that a recently described class of molecules called microRNAs (miRNAs) play an important role in regulating oogenesis, the process by which females make eggs. MiRNAs silence genes by binding to genetic elements called messenger RNA and preventing them from making new proteins -- the molecules primarily responsible for cell activities.

While previous research has identified some miRNA targets, investigators haven't yet seen how they impact developmental processes.

"We found the first evidence that miRNAs are involved in oogenesis, and this adds an extra layer of complexity that needs to be explored if we are to understand how development is regulated," said Jonathan Minden, associate professor of biological sciences at Carnegie Mellon and one of the paper's authors.

The findings will be published online the week of Aug. 8 by the Proceedings of the National Academy of Sciences (PNAS).

"If miRNAs are missing from a developing egg, then it fails to develop to term, and the net result is infertility," said lead author Richard W. Carthew, Owen L. Coon Professor of Molecular Biology at Northwestern. "It is intriguing to think that miRNA dysfunction might be at the root cause of certain forms of infertility. We already know that miRNAs are involved in cancer and stem cell biology."

Investigators were initially surprised to find that miRNAs affected only a small fraction of expressed genes within a maturing egg. On closer inspection, they found that the genes affected by miRNAs shared common roles as regulators of protein manufacturing or turnover. These results suggest that miRNAs tightly control the abundance of proteins throughout the process of oogenesis and fertilization.

Using a proteomics tool developed at Carnegie Mellon, the scientists compared maturing fruit fly eggs. One group of eggs was missing a gene ess

Contact: Megan Fellman
Northwestern University

Page: 1 2

Related biology news :

1. MicroRNA conflict resolution
2. MicroRNA works with Ago2 protein to regulate blood cell development
3. Tips from the Journals of the American Society for Microbiology
4. Microscopic jets, diamonds unlikely on Uranus, and amazing mosquito legs
5. DOE JGI upgrades its Microbial Genome Analysis System
6. Tips from the Journals of the American Society for Microbiology
7. Microbes at work cleaning up the environment
8. Tips from the Journals of the American Society for Microbiology
9. Tips from the Journals of the American Society for Microbiology
10. MicroRNAs can be tumor suppressors
11. MicroRNAs as tumor suppressors

Post Your Comments:

(Date:10/12/2015)... LONDON , Oct. 12, 2015 ... biometrics-based end-to-end authentication infrastructure company, will introduce ... which captures four prints simultaneously, providing an ... as well as discuss the new biometric ... will highlight how enterprises from financial services ...
(Date:10/9/2015)... http://www.researchandmarkets.com/research/6g9l3b/samsung_galaxy_s6 ) ... "Samsung Galaxy S6 Fingerprint Sensor - Reverse ... --> http://www.researchandmarkets.com/research/6g9l3b/samsung_galaxy_s6 ) has announced ... S6 Fingerprint Sensor - Reverse Costing Analysis" ... Research and Markets ( http://www.researchandmarkets.com/research/6g9l3b/samsung_galaxy_s6 ) ...
(Date:10/8/2015)... 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... wallet announces that revenues for the three months ... with $113,00 for the three months ended June ... September 30, 2015 were approximately $520,000. ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... FRANCISCO , October 12, 2015 ... USD 6.49 billion by 2022, according to a new report ... be attributed to rise in incidence of oncology diseases and ... market is expected to reach USD 6.49 billion by ... Inc. This growth in demand can be attributed to rise ...
(Date:10/12/2015)... October 12, 2015 DorlandsOnline.com ... version for enriched online experience --> ... to print version for enriched online experience ... media alternative to print version for enriched online ... of scientific, technical and medical information products and services, ...
(Date:10/11/2015)... ... October 11, 2015 , ... Intelligent Implant ... officially launched and multiple surgeries have been completed with this new posterior thoracolumbar ... Neuroscience & Spine Center of the Carolinas. The Revolution™ Spinal System pioneers ...
(Date:10/9/2015)... and ROCKVILLE, Md. ... ("ITI"), a privately-held biotechnology company developing next generation ... that it has entered into an exclusive worldwide ... products for the treatment or prevention of any ... of the agreement, Immunomic Therapeutics will receive an ...
Breaking Biology Technology:
Cached News: