HOME >> BIOLOGY >> NEWS
Micro RNAs play role in egg making

EVANSTON, Ill. --- Researchers at Northwestern University and Carnegie Mellon University have found that a recently described class of molecules called microRNAs (miRNAs) play an important role in regulating oogenesis, the process by which females make eggs. MiRNAs silence genes by binding to genetic elements called messenger RNA and preventing them from making new proteins -- the molecules primarily responsible for cell activities.

While previous research has identified some miRNA targets, investigators haven't yet seen how they impact developmental processes.

"We found the first evidence that miRNAs are involved in oogenesis, and this adds an extra layer of complexity that needs to be explored if we are to understand how development is regulated," said Jonathan Minden, associate professor of biological sciences at Carnegie Mellon and one of the paper's authors.

The findings will be published online the week of Aug. 8 by the Proceedings of the National Academy of Sciences (PNAS).

"If miRNAs are missing from a developing egg, then it fails to develop to term, and the net result is infertility," said lead author Richard W. Carthew, Owen L. Coon Professor of Molecular Biology at Northwestern. "It is intriguing to think that miRNA dysfunction might be at the root cause of certain forms of infertility. We already know that miRNAs are involved in cancer and stem cell biology."

Investigators were initially surprised to find that miRNAs affected only a small fraction of expressed genes within a maturing egg. On closer inspection, they found that the genes affected by miRNAs shared common roles as regulators of protein manufacturing or turnover. These results suggest that miRNAs tightly control the abundance of proteins throughout the process of oogenesis and fertilization.

Using a proteomics tool developed at Carnegie Mellon, the scientists compared maturing fruit fly eggs. One group of eggs was missing a gene ess
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
8-Aug-2005


Page: 1 2

Related biology news :

1. MicroRNA conflict resolution
2. MicroRNA works with Ago2 protein to regulate blood cell development
3. Tips from the Journals of the American Society for Microbiology
4. Microscopic jets, diamonds unlikely on Uranus, and amazing mosquito legs
5. DOE JGI upgrades its Microbial Genome Analysis System
6. Tips from the Journals of the American Society for Microbiology
7. Microbes at work cleaning up the environment
8. Tips from the Journals of the American Society for Microbiology
9. Tips from the Journals of the American Society for Microbiology
10. MicroRNAs can be tumor suppressors
11. MicroRNAs as tumor suppressors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... 1, 2016 The report "Biometric ... Future Technology (Iris Recognition System), Vehicle Type (Passenger ... Forecast to 2021", published by MarketsandMarkets, the market ... 2016, and is projected to grow to USD ... 14.06%.      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/30/2016)... Nov. 30, 2016  higi SH llc (higi) ... initiative targeting national brands, industry thought-leaders and celebrity ... respective audiences for taking steps to live healthier, ... in 2012, higi has built the largest self-screening ... 38 million people who have conducted over 185 ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint ... ... Multi-Biometric supplier: The company's Fingerprint Identification System is part of an efficient ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... Texas (PRWEB) , ... December 06, 2016 , ... Discovering ... new ways to see with lasers what’s happening in our brains. And searching for ... Texas’ rising stars in research being honored with the 2017 Edith and Peter ...
(Date:12/6/2016)... 6, 2016 According to a new market ... (Polymer, Glass, Silicon), Application (Genomics, Proteomics, Capillary Electrophoresis, POC, Clinical, Environmental, ... global market is projected to reach USD 8.78 Billion by 2021 ... during the forecast period (2016 to 2021). ... ...
(Date:12/6/2016)... MELBOURNE, Australia , Dec. 6, 2016  The ... Health Informatics Society of Australia (HISA) today announced ... technology startup exchange program between Australia ... city in the world. HISA and ... are initiating a program to create a global health ...
(Date:12/5/2016)... ... 05, 2016 , ... This composition patent, U.S. Patent No. ... The composition claims are not limited to any particular process to make or ... carbon fibers, graphene, and other materials. A continuation application, U.S. Patent App. ...
Breaking Biology Technology:
Cached News: