HOME >> BIOLOGY >> NEWS
Micro RNAs play role in egg making

EVANSTON, Ill. --- Researchers at Northwestern University and Carnegie Mellon University have found that a recently described class of molecules called microRNAs (miRNAs) play an important role in regulating oogenesis, the process by which females make eggs. MiRNAs silence genes by binding to genetic elements called messenger RNA and preventing them from making new proteins -- the molecules primarily responsible for cell activities.

While previous research has identified some miRNA targets, investigators haven't yet seen how they impact developmental processes.

"We found the first evidence that miRNAs are involved in oogenesis, and this adds an extra layer of complexity that needs to be explored if we are to understand how development is regulated," said Jonathan Minden, associate professor of biological sciences at Carnegie Mellon and one of the paper's authors.

The findings will be published online the week of Aug. 8 by the Proceedings of the National Academy of Sciences (PNAS).

"If miRNAs are missing from a developing egg, then it fails to develop to term, and the net result is infertility," said lead author Richard W. Carthew, Owen L. Coon Professor of Molecular Biology at Northwestern. "It is intriguing to think that miRNA dysfunction might be at the root cause of certain forms of infertility. We already know that miRNAs are involved in cancer and stem cell biology."

Investigators were initially surprised to find that miRNAs affected only a small fraction of expressed genes within a maturing egg. On closer inspection, they found that the genes affected by miRNAs shared common roles as regulators of protein manufacturing or turnover. These results suggest that miRNAs tightly control the abundance of proteins throughout the process of oogenesis and fertilization.

Using a proteomics tool developed at Carnegie Mellon, the scientists compared maturing fruit fly eggs. One group of eggs was missing a gene ess
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
8-Aug-2005


Page: 1 2

Related biology news :

1. MicroRNA conflict resolution
2. MicroRNA works with Ago2 protein to regulate blood cell development
3. Tips from the Journals of the American Society for Microbiology
4. Microscopic jets, diamonds unlikely on Uranus, and amazing mosquito legs
5. DOE JGI upgrades its Microbial Genome Analysis System
6. Tips from the Journals of the American Society for Microbiology
7. Microbes at work cleaning up the environment
8. Tips from the Journals of the American Society for Microbiology
9. Tips from the Journals of the American Society for Microbiology
10. MicroRNAs can be tumor suppressors
11. MicroRNAs as tumor suppressors

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Micro RNAs play role egg making

(Date:7/25/2014)... molecular testing panel developed at UPMC greatly increases ... for patients with thyroid nodules and cancer, report ... (UPCI), partner with UPMC CancerCenter., The test, available ... diagnostic testing agencies, improved the chances of patients ... according to the study published this month in ...
(Date:7/24/2014)... Scientists at The New York Stem Cell ... to creating a viable cell replacement therapy for ... , For the first time, NYSCF scientists generated ... samples of patients with primary progressive multiple sclerosis ... induce these stem cells into becoming oligodendrocytes, the ...
(Date:7/24/2014)... , July 24, 2014 /PRNewswire-iReach/ -- The Geneva ... from cardiac devices, has cut emergency room wait times ... San Diego (UCSD) Medical Center, according to a recent ... UCSD Emergency Departments are using the suite to access ... pacemakers or defibrillators. "Using Geneva,s technology platform ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
(Date:7/25/2014)... the University of Leicester has furthered our understanding ... to create new materials using nanosized ,building blocks,. ... the prestigious academic journal Physical Review Letters ... in rich detail the structure and internal atomic ... molecule and a single helium atom. , The ...
(Date:7/25/2014)... The Conferee Networking committee is pleased to ... These two-hour sessions provide a unique networking opportunity for ... discuss new techniques, or brainstorm new ideas in an ... for consideration is August 31, 2014, and instructions can ... committee will review the topics, and status notifications will ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 At the ... has granted a 60-day extension for the public comment ... Special Rule for Model Aircraft established by Congress as ... 2012. The 60-day extension establishes the new deadline for ... States Department of Transportation/FAA notice published in the Federal ...
(Date:7/24/2014)... Gain recognition for leadership and contribution ... biotech industry. Nominations are now being accepted for ... by the Bio Supply Management Alliance , ... professionals for the past 7 years. , Awards ... industry – Manufacturers, Service Providers, Material Suppliers, Technology ...
Breaking Biology Technology:Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2FAA Grants Comment Extension at the Request of AMA 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3
Cached News: