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Micro molecules contribute mightily to heart problem

DALLAS Nov. 13, 2006 -- Tiny bits of RNA a chemical cousin of DNA play a large role in causing enlargement of the heart, which is a major risk factor for heart failure and sudden death, researchers at UT Southwestern Medical Center have discovered.

Their findings, available online this week and in an upcoming issue of the Proceedings of the National Academy of Sciences, are part of a fast-growing research field revealing the wide importance of so-called micro ribonucleic acids, or miRNAs, in numerous bodily functions, including cancer, cell death and cell growth.

"They haven't been studied for very long," said Dr. Eric Olson, chairman of molecular biology and senior author of the study. "These particular micro RNAs aren't just markers of heart failure. They're actually able to cause the disease, at least in mice.

"This is the first evidence for the involvement of micro RNAs in adult heart disease," said Dr. Olson, who directs the Nancy B. and Jake L. Hamon Center for Basic Research in Cancer and the Nearburg Family Center for Basic Research in Pediatric Oncology.

Eventually, manipulating micro RNAs might be a way to treat heart disease, the researchers reported. A micro RNA can be blocked with a short complementary fragment of genetic material engineered to attach to RNA and neutralize it.

The process of identifying the damage-causing micro RNAs started with the researchers investigating whether any micro RNAs were present at abnormal levels in diseased, enlarged hearts of mice. Sixteen of the 28 such micro RNAs identified were focused on because they were similar to those found in humans and rats. The researchers found that some of the same micro RNAs are present at abnormal concentrations in diseased human hearts, suggesting that these micro RNAs also play a role in human heart disease.

Dr. Olson's team eventually zeroed in on one micro RNA, called miR-195, which had both visible and func
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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
13-Nov-2006


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