HOME >> BIOLOGY >> NEWS
MicroRNA conflict resolution

In the Aug. 1 issue of G&D, a team of Japanese scientists led by Dr. Shigeyuki Yokoyama (RIKEN and the University of Tokyo), presents heretofore the most relevant experimental system of microRNA-mediated translational repression.

Our cell-free system provides breakthrough in elucidating miRNP function, according to Dr. Yokoyama.

Their study provides unprecedented insight into how miRNAs repress translation, and helps to resolve the current conflict over the precise mechanism of miRNA action.

Dr. Yokoyama and colleagues developed a cell-free system using extracts from human epithelial cells that were engineered to over-express specific miRNA pathway components. They introduced exogenous let-7 miRNAs and monitored its effects on the translation of luciferase reporter mRNA.

The researchers found that let-7 miRNAs recruited miRNP complexes containing Ago2 and GW182 proteins to target mRNAs, resulting in mRNA deadenylation and translational repression. These findings suggest that miRNAs interfere with the initiation step of translation.


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
31-Jul-2007


Page: 1

Related biology news :

1. MicroRNA works with Ago2 protein to regulate blood cell development
2. MicroRNAs can be tumor suppressors
3. MicroRNAs as tumor suppressors
4. MicroRNA helps prevent tumors
5. MicroRNAs, alternative splicing and the muscle proteome
6. MicroRNA processing and cancer
7. MicroRNA gene that regulates lifespan found by Yale scientists
8. MicroRNA may have fail-safe role in limb development
9. MicroRNAs have shaped the evolution of the majority of mammalian genes
10. MicroRNAs play a big part in gene regulation - and evolution
11. MicroRNA tweaks protein that controls early heart development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... , ... The 19th Annual Bio-IT World Conference & ... and IT leaders goes VIRTUAL and announces its updated event features and full ... the leadership role of keeping our life science community connected by bringing you ...
(Date:8/12/2020)... ... 2020 , ... Mosio recently announced its newly updated text ... of all sizes. With a focus on tracking symptoms and monitoring outbreaks as ... Mosio helps public health departments automate communications and provide more personalized care and ...
(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval from the ... ProText™, making them the first Wharton’s jelly allografts to be assigned a Q code ... solutions are the first Wharton’s jelly allograft product to be recognized as a 361 ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... DuPont Nutrition & Biosciences announced ... The new plant operation will provide the local animal production industry with customized ... facility will improve the flexibility of our offerings to the Chinese animal nutrition ...
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. ... a global leader in FDA compliance consulting has been named on its annual ... The list represents a unique look at the most successful companies within the ...
(Date:7/31/2020)... ... 29, 2020 , ... G-CON Manufacturing, the leader in off-site ... FOR LIFE.” The adoption of this taglines comes at a time of tremendous ... to provide patients with urgently needed vaccines and other lifesaving pharmaceutical treatments. G-CON’s ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... of the top radiation centers in 16 countries, has reached its 20th anniversary ... is now in routine use at top universities including University of Pennsylvania, University ...
Breaking Biology Technology:
Cached News: