HOME >> BIOLOGY >> NEWS
MicroRNA may have fail-safe role in limb development

GAINESVILLE, Fla. - A tiny strand of molecules plays a role in how our arms and legs develop and grow - a finding that sheds light on perplexing bits of material once dismissed as genetic "junk," say scientists at the University of Florida and Harvard University.

The research, available today in the online edition of Nature, may help scientists understand whether bits of RNA called microRNAs act as protective mechanisms in healthy development not just by strategically turning off gene activity, but by making sure it stays turned off.

More specifically, researchers report linking a specific microRNA - miR 196 - to limb development, a finding that may be useful in understanding birth defects.

Until about five years ago, genetic researchers focused on DNA, which contains all the genetic instructions for the human body, and RNA, which translates DNA's message into proteins - the building blocks of cells, organs and all of the various systems of the body.

Unnoticed next to the main ingredients, microRNAs were considered to be "junk" DNA, leftovers from millions of years of evolution. More recently, this genetic material is suspected to be part of an intricate mechanism that helps repress about one-third of our 25,000 genes. It has been linked to diabetes, hepatitis C, leukemia, lymphoma and breast cancer.

But only now have microRNAs been connected to actual growth processes.

"We found miR 196 expressed only in the hindlimbs of mice, not the forelimbs - in other words, the feet but not the hands," said Brian Harfe, Ph.D., an assistant professor of molecular genetics and microbiology in the College of Medicine and a member of the UF Genetics Institute. "In developmental biology, there has always been debate about why forelimbs are different from hindlimbs. We now think this microRNA is regulating something important in the hindlimbs but not in the forelimbs."

Scientists do not know exactly what is happening, but they
'"/>

Contact: John Pastor
jpastor@vpha.health.ufl.edu
352-273-5815
University of Florida
1-Dec-2005


Page: 1 2

Related biology news :

1. MicroRNA conflict resolution
2. MicroRNA works with Ago2 protein to regulate blood cell development
3. MicroRNAs can be tumor suppressors
4. MicroRNAs as tumor suppressors
5. MicroRNA helps prevent tumors
6. MicroRNAs, alternative splicing and the muscle proteome
7. MicroRNA processing and cancer
8. MicroRNA gene that regulates lifespan found by Yale scientists
9. MicroRNAs have shaped the evolution of the majority of mammalian genes
10. MicroRNAs play a big part in gene regulation - and evolution
11. MicroRNA tweaks protein that controls early heart development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/26/2019)... ... October 24, 2019 , ... ... manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, today ... at the forthcoming American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 at ...
(Date:10/22/2019)... , ... October 21, 2019 , ... Join QPS ... Director of Bioanalytical in a live session on Thursday, October 31, 2019 ... partner. , A good CRO partner should have expertise in method development, which ...
(Date:10/17/2019)... ... 2019 , ... The scope of the quality system covers ... manufactures ready-to-use culture broth and buffers in its proprietary MediaBox™ format, bottles & ... This major step underpins the company’s philosophy of offering the highest quality equipment ...
Breaking Biology News(10 mins):
(Date:11/6/2019)... ... , ... Diversified Technologies, Inc. has introduced a PEF production system ... improve processing. , The DTI Industrial PEF Unit can pre-treat whole pieces of fruits ... by up to 50% and achieve up to an 80% reduction of drying energy. ...
(Date:11/5/2019)... ... November 05, 2019 , ... ... has received CE Mark for its Fusion Bx 2.0 prostate fusion biopsy solution. ... interface, the Fusion Bx 2.0 will give urologists across Europe the ability to ...
(Date:11/2/2019)... ... October 31, 2019 , ... Join Patrick Raber, ... live webinar on Friday, November 15, 2019 at 1pm EST to ... science of profiling T-cell receptors (TCRs) and B-cell receptors (BCRs), has been widely ...
(Date:10/30/2019)... ... October 30, 2019 , ... Western ... many roles innovation and technology play in educating the next generation of health ... learning opportunities and presentations by WesternU administrators and representatives of companies working with ...
Breaking Biology Technology:
Cached News: