HOME >> BIOLOGY >> NEWS
Microtubule protein interactions visualized en masse

In a new study published online in the open access journal PLoS Biology, Philipp Niethammer, Eric Karsenti, and colleagues investigate the regulation of microtubule dynamics via application of their new method, called visual immunoprecipitation (VIP), which enables simultaneous visualization of multiple protein interactions in cell extracts.

When eukaryotic cells undergo cell division, a dramatic reorganization occurs during the transition from interphase to metaphase. The cell rounds up, chromosomes condense, the nuclear envelope breaks down, and microtubules (proteins that help maintain the cell's shape) become very short and dynamic before assembly of the mitotic spindle (the structure that pulls chromosomes apart). Although it is known that the CDK1 kinase induces this reorganization, the precise mechanisms that regulate such coordinated changes are not yet understood.

There are two known major regulators of microtubule dynamics: a stabilizer (XMAP215) and a destabilizer (XKCM1); a series of other molecules (EB1, APC, and CLIP 170) are also involved, although their roles in the global regulation of microtubule dynamic instability are not as clear. Using VIP, these researchers show that microtubules are stable during interphase because the destabilizer is inhibited by the other molecul es. During mitosis, however, the destabilizer is released, triggering the alteration of microtubule structure and dynamics. Thus, microtubule dynamics change in response to a dramatic switch in the interactions of a set of proteins.


'"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
15-Jan-2007


Page: 1

Related biology news :

1. Microtubules critical to development of mental disorders
2. Penn researchers discover how key protein stops inflammation
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
5. Discovery of new protein could provide new understanding of male fertility
6. Unlocking proteins from their cellular shell
7. Altering a protein makes mice less fearful
8. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
9. MicroRNA works with Ago2 protein to regulate blood cell development
10. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
11. Call for EU to launch major project to map out all our proteins

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Microtubule protein interactions visualized masse

(Date:2/9/2015)... -- Lintec of America recently announced an exclusive license to ... including sheets, yarns and ribbons, developed at the University ... vast industrial resources of the global Lintec Group, headquartered ... America is forming the Nano-Science and Technology Center (NSTC) ... scaling up the manufacturing and commercialization of nano engineered ...
(Date:2/5/2015)... IRVINE, Calif. , Jan. 27, 2015 ... trusted provider of globally deployed, innovative test ... today announced the delivery of its ... Martin Space Systems Company (LMSSC). GENASYS is ... the demands of mission-critical applications that require ...
(Date:2/5/2015)... Calif. , Feb. 3, 2015 ... technology, demand from industries such as consumer electronics, ... market for surface mount technology (SMT) screen printers. ... to automatic control will push the adoption curve ... will remain steady as glue dispensers are indispensable ...
Breaking Biology News(10 mins):Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3
(Date:3/5/2015)... 2015 e2b teknologies , a ... in Northeast Ohio, today announced a leading independent multi-specialty ... its upgrade to the latest version of Sage ... practice of its kind in the region, the organization ... transactions, so efficiency and data accessibility are paramount to ...
(Date:3/4/2015)... -- The UPMC Center for Health Security today announced ... Leaders in Biosecurity Initiative (ELBI). As part of our ... biosecurity, UPMC has selected 28 US and international emerging ... including biological science, medicine, policy, the military, think tanks ... vision and support of the Defense Threat Reduction Agency ...
(Date:3/4/2015)... , March 4, 2015 /CNW/ - Resverlogix Corp. ... has completed a collaborative research program with ...  Using Fast Collective Evolution Technology (FACET), Emerald ... all measurements obtained from each of 798 ... 2 clinical trials ASSERT, SUSTAIN and ASSURE. ...
(Date:3/4/2015)... 4, 2015 Vegalab announced the acquisition of ... last year. As part of the acquisition, Ecowin rebranded ... continuing his role as CEO for the company,s Korea ... will work alongside Koo and oversee developments at the ... Koo founded Ecowin in 2008 ...
Breaking Biology Technology:Physician Group Practice Chooses e2b teknologies to Support Its Upgrade to Sage 100 ERP 2014 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4Korean Government Program Supports Vegalab's Research and Development 2Korean Government Program Supports Vegalab's Research and Development 3
Cached News: