HOME >> BIOLOGY >> NEWS
Migration alert -- How tumor cells home in on the lymphatic system

A Swiss-based research team has published a new mechanistic description of how tumor cells migrate to the lymphatic system in the early stages of tumor metastasis. This new understanding holds significant potential for developing anti-metastasis therapies.

Scientists know that tumor cells spread via the lymphatic system, but they dont understand the details of how this deadly migration takes place. In the June 2007 issue of the journal Cancer Cell, EPFL Professor Melody Swartz and postdoctoral researcher Jacqueline Shields provide an explanation along with data to support it.

Tumors produce excess fluid that continually percolates from the tumor towards nearby lymphatic vessels. The EPFL research shows how tumor cells use a clever chemical strategy to exploit this slow, one-way flow in order to migrate to functional lymphatic vessels.

As part of their intercellular drainage job, lymphatic tissues secrete small quantities of a signaling molecule. Cells migrate towards high concentrations of this molecule, so if they are close enough to the lymphatic to sense the molecule, they will migrate towards the vessel. Swartzs group showed that tumor cells secrete this same molecule. Since lymphatics drain fluid, there will always be slow fluid flow going away from the tumor into the lymphatic vessel. This slow flow biases the concentration distribution of this molecule towards the lymphatic, and the tumor cell follows it, like the proverbial carrot on a stick. Near the vessel, concentrations of the signaling molecule are reinforced by the lymphatics own secretions, fine tuning the tumor cells migration and guaranteeing that they will home in on the lymphatic.

To demonstrate this new concept, the researchers engineered a tissue culture model of the tumor-lymphatic microenvironment and developed computational models to calculate the gradients of the signaling molecule.

The study provides the first evidence that tumor ce
'"/>

Contact: Melody Swartz
melody.swartz@epfl.ch
41-216-939-686
Ecole Polytechnique Fdrale de Lausanne
11-Jun-2007


Page: 1 2

Related biology news :

1. Migration study finds that sweeping management changes are needed to protect Atlantic bluefin tuna
2. Polycystic kidney disease: MRI provides an early alert to progression
3. Media alert: New study finds dairy is not associated with weight gain
4. Media alert A look forward and a look back: 50 years of crop science
5. Media alert: Special session on the impact of Hurricanes Katrina, Rita on crops, soils, environment
6. Media alert: Special sessions feature Utahs military, agriculture connections
7. New study finds how cells with damaged DNA alert the immune system
8. Invasion of the brain tumors
9. Multicenter study nets new lung tumor-suppressor gene
10. Defects in critical gene lead to accelerated lung tumor growth
11. A friendly foe -- Bacteria residing in the gut boost immune response to tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 17, 2019 , ... ... practice in the Southeast, and its acclaimed pediatric urologists are among the ... rankings. This annual recognition signifies excellence among the country’s pediatric healthcare landscape. ...
(Date:7/11/2019)... ... July 11, 2019 , ... ... DNA test, today announced a partnership with LiquiTech, a leader in Legionella ... strategic partnership, LiquiTech will integrate Spartan’s innovative environmental DNA testing platform to ...
(Date:7/9/2019)... ... July 08, 2019 , ... On June 27, 2019, ... the innovation behind two Danisco amylase patent applications (EP2859097 and EP2825643). The court ... prior art was without merit and awarded costs to Danisco. , “Testimony ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... TOWNSHIP, N.J. (PRWEB) , ... May 13, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... new Heliumleak.com company website. The redesigned website aims to improve LDA’s ability to ...
(Date:5/8/2019)... ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large ... a drill team and barrel racing, among other activities. When loping around a corner ... went from being a busy horse to only being able to walk. Fortunately Atlas’ ...
(Date:5/4/2019)... ... May 03, 2019 , ... ... of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, ... (DF). Urandir detailed the results of some research carried out by the association, ...
(Date:5/2/2019)... Md. (PRWEB) , ... April ... ... to the International Organization for Standardization ISO 9001:2015 standard, REPROCELL USA Inc. ... meet customer requirements. In addition, REPROCELL USA Inc. aims to enhance customer ...
Breaking Biology Technology:
Cached News: