HOME >> BIOLOGY >> NEWS
Mispairs in genetic material make protein synthesis more efficient

MADISON- The wealth of information contained in a strand of genetic material boils down to sequences of matched pairs of nucleotides that cellular machinery decodes to construct proteins.

Writing today in The Proceedings of the National Academy of Sciences, a University of Wisconsin-Madison bacteriologist reveals that mispaired nucleotides in transfer RNA actually make the molecule more adroit, enhancing its ability to build proteins. The paper also illustrates the dynamic nature of genetic material, which is not flat, like an illustration in a textbook, but twists and bends as it interacts with cellular machinery.

The mispairs, also called "wobble pairs," do not bind together as tightly as matched pairs bind, making transfer RNA "a compressed spring ready to be sprung," according to William McClain, a professor of bacteriology in the UW-Madison's College of Agricultural and Life Sciences and the author of the PNAS paper. He notes that specific transfer RNA mispairs, which likely originally arose through natural mutation, are highly conserved across all kingdoms of life, providing evidence that they play an important role in making the molecule more reactive.

Genetic information is encoded in DNA, which is made up of matched base pairs of adenine and thymine, and guanine and cytosine - commonly denoted with the letters A, T, G and C. Cellular machinery transcribes the information from DNA into RNA - where the base uracil replaces thymine -- and then translates the coded data into proteins, which form the building blocks of life.

Scientists have long known that transfer RNA - which adds amino acids to a growing chain during protein synthesis - holds a surprising secret when it comes to its base pairs: occasionally, instead of the expected A-U or G-C pairs, there exists instead a mispair of A-C or G-U. However, the role and importance of mispairs has never been well understood, says McClain.

McClain, who has spent his caree
'"/>

Contact: William McClain
wmcclain@wisc.edu
608-262-3054
University of Wisconsin-Madison
6-Mar-2006


Page: 1 2

Related biology news :

1. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
2. Does the desire to consume alcohol and tobacco come from our genetic makeup?
3. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
4. Penn researchers discover pathway that eliminates genetic defects in red blood cells
5. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
6. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
7. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
8. Identified main genetic variants involved in response to HIV
9. Restless legs genetics on the move
10. UK scientists lift lid on genetics of coronary artery disease
11. Global community listens to TAU genetic researcher at EU Conference on Hearing Loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... ... August 15, 2019 , ... ... what? As serialization mandates become increasingly complex, and aggregation becomes fully applied in ... software is the best long-term solution. , Until now, most regulations?including the Drug ...
(Date:8/14/2019)... , ... August 14, 2019 , ... ... 4Q/2019, will explore how developments in microbiome therapeutics are helping to promote normal ... for more information. , Advancements will educate about the DECODE.DESIGN.CURE™ technology platform, which ...
(Date:8/14/2019)... TORONTO (PRWEB) , ... August 14, 2019 , ... Join ... live session on Tuesday, September 10, 2019 at 1pm EDT to learn ... stratification and effective management. , NAFLD is the most common diffuse liver disease, ...
Breaking Biology News(10 mins):
(Date:7/19/2019)... AUBURN, Mass. (PRWEB) , ... July 18, 2019 ... ... PI (Physik Instrumente) announced their investment to enlarge their current piezo motion facilities ... building will offer 3 floors for multilayer piezo ceramic assembly production in addition ...
(Date:7/17/2019)... COLLEGE PARK, Md. (PRWEB) , ... July 15, 2019 , ... ... cut DNA so that a certain trait can be removed, replaced, or edited, but ... Maryland, is looking far beyond these traditional applications in his latest publication in Nature ...
(Date:7/17/2019)... ... July 16, 2019 , ... Quidel is ... from Kalorama Information. Abbott, Roche and Siemens Healthineers and Response Biomedical also are ... Worldwide Market for Point-of-Care (POC) Diagnostics . , Quidel is a market ...
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the BIO World Congress ... Growers Association (NCGA) announced the winners of the Consider Corn Challenge II. Three ... using field corn to produce biobased materials. , “Corn is a sustainable, abundant ...
Breaking Biology Technology:
Cached News: