HOME >> BIOLOGY >> NEWS
Missing steps of jumping-gene replication discovered

In experiments with transgenic mice, University of Pennsylvania School of Medicine researchers discovered the remaining steps in the complicated process of how the largest class of jumping genes replicates and inserts themselves within the human genome. Haig H. Kazazian, Jr. MD, Chair of the Department of Genetics, and colleagues at Penn published their findings in the February issue of Genome Research. This knowledge may shed light on the origins of "junk" DNA, parts of the genome for which no function has yet been discovered.

Jumping genesalso called mobile DNA or transposonsare sequences of DNA that can move or jump to different areas of the genome within the same cell. They are a rare cause of several genetic diseases, such as hemophilia and Duchenne muscular dystrophy.

Retrotransposons are one class of jumping genes, with the L1 family being the most abundant in the human genome. Retrotransposons move by having their DNA sequence transcribed or copied to RNA, and then instead of the genetic code being translated directly into a protein sequence, the RNA is copied back to DNA by the retrotransposon's own enzyme called reverse transcriptase. This new DNA is then inserted back into the genome. This process of copying is similar to that of retroviruses, such as HIV, leading scientists to speculate about a viral origin for retrotransposons.

"L1 retrotransposons, which are the only active mobile DNA elements in humans, have accounted for about 30 percent of the human genome by their own insertions and by driving the insertion of other kinds of elements," says Kazazian. "In fact, humans have over 500,000 L1 retrotransposons within an individual genome."

In order to learn about the effects of L1 retrotransposon insertions into the human genome, the researchers made a transgenic mouse in which human L1 retrotransposons could replicate. They injected several copies of a human L1 retrotransposon to create the transgenic mouse. In subsequ
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
31-Jan-2006


Page: 1 2 3

Related biology news :

1. Protein tied to usher syndrome may be hearings Missing Link
2. Missing breast cancer genes may soon be discovered
3. Missing fossil link Dallasaurus found
4. Missing micronutrients - How best to nourish a child?
5. Found: Missing sequence of the human Y chromosome
6. How cells change the pace of their steps
7. Sox17 required for steps from embryonic to heart muscle cell
8. Penn researchers discover initial steps in the development of taste
9. For Stanford scientists, RNAi gene therapy takes two steps forward, one step back
10. Discovering the first steps in transcription-coupled repair
11. Stressed cells spark DNA repair missteps and speed evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... 2016 Research and Markets has announced the ... report to their offering. The ... to grow at a CAGR of 12.28% during the period ... an in-depth market analysis with inputs from industry experts. The report ... years. The report also includes a discussion of the key vendors ...
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/21/2016)... , June 21, 2016 NuData ... the new role of principal product architect and ... the director of customer development. Both will report ... technical officer. The moves reflect NuData,s strategic growth ... response to high customer demand and customer focus ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... Antonio Texas (PRWEB) , ... ... ... today that it will share findings demonstrating the value of DNA microarray ... patients at this year’s San Antonio Breast Cancer Symposium. Using molecular test ...
(Date:12/2/2016)... ... December 01, 2016 , ... DrugDev believes the ... and a beautiful technology experience. All three tenets were on display at the 2nd ... leaders from over 40 sponsor, CRO and site organizations to discuss innovation and the ...
(Date:12/2/2016)... 2016   SurePure, Inc. (OTCQB: SURP) a ... Company has concluded an agreement with Tamarack Biotics under ... period to acquire units of the Company,s patented photopurification ... million.  Concurrently with the option, SurePure ... Tamarack will seek regulatory approvals in the ...
(Date:11/30/2016)... -- GenomOncology today announced the appointment of Joshua F. Coleman ... Dr. Coleman will oversee clinical content development and curation ... GenomOncology software suite empowers molecular pathologists with a seamless workflow ... support, from quality control through reporting. ... , , ...
Breaking Biology Technology:
Cached News: