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Missing steps of jumping-gene replication discovered

snapshot of a large number of new L1 jumps in a situation closely mimicking what occurs every day in the human genome," says Babushok. "Importantly, occasional small additions of extra DNA sequences at the ends of new L1 insertions gave us tantalizing leads to the L1 retrotransposon replication mechanism. We are very excited to follow this thread to confirm our proposed mechanism and to come closer to a complete understanding of the interaction between L1 retrotransposons and our genomes."


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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
31-Jan-2006


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