Mitochondrial DNA variants linked to renal, prostate cancer

Anaheim, Calif. It's often called the 'powerhouse" of the cell because this is where sugar is broken down to release energy required for cell function.

But mitochondria also contain a small amount of DNA that's used to manufacture 13 of the proteins needed for all these activities.

Now, scientists at Emory University have discovered that mitochondrial DNA contains signature sequencing that is associated with two times the risk for prostate and up to two-and-one-half times the risk for renal cancer.

"The inheritance of mitochondrial haplotype is important in cancer disposition," said John Petros, M.D., associate professor of urology at Emory University and The Atlanta VA Medical Center. A haplotype is a combination of variations in a gene.

Like an asterisk fixed alongside the human genome, mitochondrial DNA (mtDNA) contains additional inherited genetic information that is passed primarily from mother to offspring. Petros identified the U haplotype as a signal for increased risk of prostate and renal cancer.

"There is also inheritance of missense mutations in at least one mitochondrial gene that is important in prostate cancer," Petros said. Missense mutations in genes lead to amino acid substitutions in the protein encoded by the gene. Among mitochondrial genes, several missense mutations in the cytochrome C oxidase subunit I (COI) gene predisposed men to increased risk for prostate cancer as well, Petros' research indicated.

The U haplogroup is one of many segments of the human population that can be grouped according to the evolutionary quirks embedded with their mtDNA. The U haplotype developed among people migrating to northern and Eastern Europe thousands, or even tens of thousands of years ago. People who carry the U haplotype mtDNA belong to the U haplogroup.

Petros determined that among Caucasian Americans, the U haplogroup makes up 9.6 percent of the general population, but a disproportionate numbe

Contact: Russel Vanderboom
American Association for Cancer Research

Page: 1 2

Related biology news :

1. Mitochondrial genes move to the nucleus -- but its not for the sex
2. Mitochondrial DNA sequencing tool updated
3. Mitochondrial biology gets a new chaperone
4. Mitochondrial DNA mutations play significant role in prostate cancer
5. Mitochondrial mutation linked to blood pressure and cholesterol problems
6. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
7. Identified main genetic variants involved in response to HIV
8. Which genome variants matter?
9. Gene variants reveal susceptibility to cardiovascular disease
10. Three human gene variants appear to influence tb susceptibility
11. Is brain size linked to two common gene variants?

Post Your Comments:

(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC , ... that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) ... with severe COVID-19. This is the first study of an XPO1 inhibitor in ...
(Date:6/23/2020)... ... 23, 2020 , ... First Aid Africa, a Scottish charity ... and manufacturer of innovative portable renewable energy equipment, have announced the success of ... COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable solar power ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku Corporation ... next event in a series of TOPIQ webinars, which will cover the Transferable ... was developed in response to social distancing measures that resulted in postponements and ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Slone Partners , ... announced the placement of Julianne Averill , CPA, as Chief Financial Officer ... operations and implementing key business strategies to accelerate Alveo’s growth as the company ...
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , ... of its Scientific Advisory Board (SAB) to research the medical potential of terpenes and ... enhanced when combined with terpenes. The board is focused on expanding the recently launched ...
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/12/2020)... , ... August 12, 2020 , ... ... (EMMA International), a global leader in FDA compliance consulting has been named ... fastest-growing private companies. The list represents a unique look at the most successful ...
Breaking Biology Technology:
Cached News: