HOME >> BIOLOGY >> NEWS
Model predicts colon cancer inheritable genetic defects

Researchers from the Johns Hopkins University and other institutions have developed a new prediction model for genetic defects known as Lynch syndrome, which predisposes families to develop colorectal cancer. The model, called MMRpro, is based on an individual's detailed family history of colorectal and endometrial cancer, as well as knowledge of how genetic mutations manifest themselves--in the form of tumors. It can assess a person's probability of carrying a particular defect within so-called mismatch repair genes. The study is published in the September 27, 2006, issue of the Journal of the American Medical Association (JAMA).

"Genetic defects can be passed from parents to their children; as a result, colon cancer runs in families. Our model will help identify individuals likely to have particular genetic defects. The results will give them useful information about their colon cancer risk before they decide whether to undergo invasive screenings or expensive genetic testing," said Sining Chen, PhD, lead author of the study and an assistant professor in the Johns Hopkins Bloomberg School of Public Health's Department of Environmental Health Sciences.

Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is characterized by the inheritance of defects in the MLH1, MSH2 and MSH6 genes. These three genes help repair mismatches that can occur during the duplication of the genetic code when new cells are made, and are known as mismatch repair (MMR) genes. Of the projected 600,000 MMR mutation carriers in the United States, each has approximately a 50 percent chance of being diagnosed with colorectal cancer by age 70. Women also have a 50 percent chance of developing endometrial cancer, explained Giovanni Parmigiani, PhD, senior author of the study and a professor of oncology, biostatistics and pathology at Johns Hopkins University.

The researchers applied MMRpro software to 279 individuals' family histories. The study pa
'"/>

Contact: Kenna L. Lowe
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
26-Sep-2006


Page: 1 2

Related biology news :

1. Modeling the restless brain
2. Modeling lung cancer
3. Modeling alien invasions: Plasticity may hold the key to prevention
4. Symposium Environmental Change in Siberia -- Insights From Earth Observation and Modeling
5. Burnham Institute for Medical Research & UC San Diego establish Joint Center for Molecular Modeling
6. Students from U of Colorado at Boulder and Harvard triumph in SIAMs Math Contest in Modeling
7. Modeling head and neck cancers
8. Modelling virtual dogs: Its a walk in the park!
9. Model identifies genes that induce normal skin cells to become abnormal
10. Model simulates dynamics of heart rhythm disorders
11. Gene predicts better outcome as cortex normalizes in teens with ADHD

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... CITY, Calif. (PRWEB) , ... July 01, 2020 ... ... biotech company, presented its phase 1a findings of Neihulizumab, a biologic for the ... conference in June 2020. Led by hemato-oncologist Dr. Paul J Martin of the ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... biopharmaceutical R&D, today announced that it has entered into a multi-year contract ... (Multiclonics®), to support their translational and clinical research strategy to discover and ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, a ... UK supplier and manufacturer of innovative portable renewable energy equipment, have announced the ... against the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... LEXINGTON, Mass. (PRWEB) , ... August 11, 2020 ... ... awarded $300,000 a year to expand the Facioscapulohumeral Muscular Dystrophy Clinical Trial ... year in 2021 and 2022. The network is a consortium of academic research ...
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, ... it has closed on the purchase of greenfield for a new, expanded manufacturing ... includes over 21 acres in the initial acquisition, with an option to purchase ...
(Date:7/31/2020)... ... , ... R3 Stem Cell International is now offering patients the opportunity to ... total, patients may choose which extremities they would like treated. , Several studies have ... 2016). At R3 International, umbilical cord tissue is obtained from a lab with a ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has introduced ... materials for use with CRM, neurostimulation, vascular, and related devices. , Anomet ... design requirements, performance, and cost criteria; especially where solid wire is limited. Typical ...
Breaking Biology Technology:
Cached News: