Modeling lung cancer

In a new report in the February 15th issue of G&D, Dr. Martin McMahon (UCSF) and colleagues present a novel mouse model of non-small cell lung cancer, which will serve as a useful tool to test the efficacy of novel chemotherapeutic drug therapies in the early stages of lung tumorigenesis. Their paper provides evidence to support the use of a relatively new class of drugs, called MEK inhibitors, for lung cancer patients whose tumors contain mutations in the BRaf gene.

BRaf is one of three members of the RAF kinase family, which, upon activation, induces the mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) cell signaling pathway and promotes cell proliferation. Activating mutations in BRaf (ie., a mutation that causes the activation of the catalytic activity of the BRaf protein) are implicated in a number of different human cancers, including the majority of melanoma cancers, as well as in colorectal, thyroid, ovarian and non-small cell lung cancers.

Dr. McMahon and colleagues engineered a strain of mice to carry a version of the BRaf gene that the researchers could activate at will both temporally and spatially. After activating BRaf specifically in the lungs of mice at 6-8 weeks of age, the researchers observed that the BRaf-mutant mice (or BRaf(VE), as they are known) developed multiple lung tumors that were pathologically similar to human lung tumors thereby establishing BRaf as a bona fide oncoprotein.

Administration of the MEK-inhibitor, PD0325901 (developed by Pfizer, and now in clinical trials) effectively halted tumor progression in BRaf(VE) mice. Interestingly, however, without pharmacological intervention, the BRaf-mutant tumors eventually stopped proliferating, and entered into a senescent state. This senescent state could be overcome by concomitant mutation of either p53 or p16(Ink4a)/p19(Arf), enabling tumors to become adenocarcinomas.

Dr. McMahon said that the striking response

Contact: Heather Cosel
Cold Spring Harbor Laboratory

Page: 1 2

Related biology news :

1. Modeling the restless brain
2. Modeling alien invasions: Plasticity may hold the key to prevention
3. Symposium Environmental Change in Siberia -- Insights From Earth Observation and Modeling
4. Burnham Institute for Medical Research & UC San Diego establish Joint Center for Molecular Modeling
5. Students from U of Colorado at Boulder and Harvard triumph in SIAMs Math Contest in Modeling
6. Modeling head and neck cancers
7. Protein chatter linked to cancer activation
8. Newly created cancer stem cells could aid breast cancer research
9. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
10. ESF EURYI award winner aims to stop cancer cells reading their own DNA
11. No evidence that widely prescribed statins protect against prostate cancer

Post Your Comments:
TAG: Modeling lung cancer

(Date:9/29/2015)... , Sept. 29, 2015 ... employee productivity while also saving energy , Minimized ... as Low Power Active Mode and embedded Fujitsu PalmSecure ... Fujitsu today shows that good things ... and refreshed models to its enterprise desktop and mobile ...
(Date:9/28/2015)... 2015 The global image ... 12.03 billion by 2020, growing at a CAGR of ... Backside Illumination (BSI) technique to improve picture quality are ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757) , The ... reduce loss and, thus, reduce the noise interference and ...
(Date:9/24/2015)... YORK , Sept. 24, 2015  EyeLock LLC, ... be showcasing its award winning and latest technology in ... Anaheim, California . EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
Breaking Biology News(10 mins):
(Date:10/8/2015)... CARDIFF, UK (PRWEB) , ... October 08, 2015 , ... ... to literally see inside the living brain, providing a new tool to study how ... work is reported by Woo June Choi and Ruikang Wang of the UW Department ...
(Date:10/8/2015)... 8, 2015  Genetic testing for mutations beyond those ... of more couples at risk of having a child ... at the 2015 American Society of Human Genetics (ASHG) ... Baltimore, Maryland . The study is one ... DGX ) are presenting at the conference this week ...
(Date:10/8/2015)... -- Celemics, a global pioneer of personalized medicine genetics, ... with the establishment of Celemics America, Inc. ... , has secured itself in the global market ... preparation for DNA sequencing and genetic testing.  Next Generation ... testing more accurately, quickly, and cost effectively than traditional ...
(Date:10/8/2015)... The 2015 Nobel Prize in Chemistry has been awarded ... Aziz Sancar , who earned his PhD in molecular and ... is one of three scientists who received the Nobel Prize for ... on a molecular level.  --> Aziz Sancar , who ... Dallas in 1977, is one of three scientists ...
Breaking Biology Technology:
Cached News: