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Modified herpes virus keeps arteries 'free-flowing' following procedures

f the arterys endothelial layer, which forms the inner lining of the artery. Loss of this inner layer predisposes the artery to blood clot formation which has been a recent concern with drug eluting stents. The researchers found that the endothelial layer was partially restored at 14 days and completely restored at 28 days post-balloon angioplasty in the group treated with the herpes virus.

The ability to target the smooth muscle cells that cause the narrowing, and regenerate the endothelial cell lining is an important finding, noted Skelly.

This study is an important step in the application of genetically engineered herpes simplex viruses for treatment of vascular disease," Skelly added. "It suggests that genetically engineered viruses may have a significant impact on the outcomes of angioplasty performed in humans. Human trials would be the next step to test this theory.


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Contact: Scot Roskelley
scot.roskelley@uchospitals.edu
773-795-0892
University of Chicago Medical Center
10-Jul-2007


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