HOME >> BIOLOGY >> NEWS
Modified mushrooms may yield human drugs

Mushrooms might serve as biofactories for the production of various beneficial human drugs, according to plant pathologists who have inserted new genes into mushrooms.

"There has always been a recognized potential of the mushroom as being a choice platform for the mass production of commercially valuable proteins," said Charles Peter Romaine, who holds the John B. Swayne Chair in spawn science and professor of plant pathology at Penn State. "Mushrooms could make the ideal vehicle for the manufacture of biopharmaceuticals to treat a broad array of human illnesses. But nobody has been able to come up with a feasible way of doing that."

Dr. Romaine and his colleague, Xi Chen, then a post-doctoral scholar at Penn State and now a Syngenta Biotechnology Inc. research scientist, have developed a technique to genetically modify Agaricus bisporus -- the button variety of mushroom, which is the predominant edible species worldwide. One application of their technology is the use of transgenic mushrooms as factories for producing therapeutic proteins, such as vaccines, monoclonal antibodies, and hormones like insulin, or commercial enzymes, such as cellulase for biofuels.

"Right now medical treatment exists for about 500 diseases and genetic disorders, but thanks to the human genome project, before long, new drugs will be available for thousands of other diseases," Dr. Romaine said. "We need a new way of mass-producing protein-based drugs, which is economical, safe, and fast. We believe mushrooms are going to be the platform of the future."

To create transgenic mushrooms, researchers attached a gene that confers resistance to hygromycin, an antibiotic, to circular pieces of bacterial DNA called plasmids, which have the ability to multiply within a bacterium known as Agrobacterium.

The hygromycin resistance gene is a marker gene to help sort out the transgenic mushroom cells from the non-transgenic cells, Dr. Romaine explained. "What w
'"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
22-Jun-2007


Page: 1 2

Related biology news :

1. Modified herpes virus keeps arteries free-flowing following procedures
2. New method shows mushrooms a top source for one antioxidant
3. Chemical analysis of mushrooms shows their nutritional benefits
4. Lost forest yields several new species
5. Natures secrets yield new adhesive material
6. Sequencing method yields fuller picture
7. St. Jude study yields secrets of chromosome movement
8. Virus widely used in gene therapy research yields important clues to genomic instability
9. From ink to optics, study of particle mixtures yields fundamental insights
10. Cooperative science program yields results
11. Supermap of avian flu yields new info on source/spread

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/11/2019)... ... 10, 2019 , ... Improved Pharma LLC announces the publication of “Predictive and ... The article was published online on April 29th, 2019. The authors are Stephen ... Chen of Purdue University. , The article is the most recent addition to a ...
(Date:6/6/2019)... ... June 05, 2019 , ... Pelican BioThermal , ... station and service center in Mexico City, Mexico. Mexico is the second largest ... more than $1.75 billion in pharmaceutical exports since 2015. The Mexico City network ...
(Date:6/4/2019)... ... June 04, 2019 , ... In’Tech Medical SAS ( ... Q1-19 revenues of $31M, up 12% from Q1-18. The growth is associated with ... & operational excellence initiatives worldwide. , Laurent Pruvost , President & CEO ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... ... 24, 2019 , ... Inference Solutions , a global ... announced global availability of Inference Studio’s latest version, which makes it easier for ... the power of Google’s Contact Center AI (CCAI). , As consumers ...
(Date:4/16/2019)... ... April 16, 2019 , ... On April 24th, the Federal ... Army Center for Environmental Health Research (USACEHR), with an award for their cooperative ... a veteran-owned company located at the Frederick Innovative Technology Center, Inc. (FITCI) on ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., a developer ... bench plant expansion to increase production of methylene malonate monomers and oligomers. , ... of Sirrus’ full-scale production facility, which is scheduled to break ground in 2019. ...
(Date:4/10/2019)... ... April 10, 2019 , ... ... into multiple agreements to help companies advance their innovations to clinical testing ... from synthetic biology companies that are gene editing therapeutic cells for advanced ...
Breaking Biology Technology:
Cached News: