HOME >> BIOLOGY >> NEWS
Molecular cabal contributes to stroke damage

In the neural train wreck that is stroke, the cutoff of oxygen kills brain cells through a buildup of acid, as well as by overexciting receptors on the surface of brain cells. Now, researchers exploring the detailed mechanism of this excitotoxicity and acidotoxicity have discovered how an insidious chain of molecular events contributes to its damage. In an article in the November 23, 2005, issue of Neuron, Jun Gao and colleagues say that their findings could contribute to the development of drugs to protect against the molecular "cabal" that produces such lethality.

In their experiments, the researchers discovered the molecular mechanism linking two key components of neuronal damage due to oxygen starvation, or ischemia. One component is a type of receptor called an NMDA receptor (NMDAR). This receptor is triggered by glutamate, which is known to be released during ischemia.

The other component of neuronal damage that they studied is an "acid-sensing ion channel," (ASIC)--basically, a pore-like protein in the membranes of neurons. In response to the acid unleashed by ischemia, ASICs open to admit calcium into the cell, and calcium overload is central to neuronal death.

In their experiments, Gao and colleagues induced ischemia in rat brains, or deprived cultured neurons of oxygen, and analyzed the molecular effects. Their analyses revealed that such deprivation triggered NMDARs, which in turn activated an important cell switch called CaMKII. This enzyme, they found, acts on a particular ASIC, called ASIC1a, to greatly enhance its sensitivity to the acid induced by ischemia. This increased sensitivity causes the ASIC channel to open and flood the neuron with lethal doses of calcium.

Importantly, the researchers found in cultures of neurons that drugs that inhibited NMDAR or CaMKII prevented the ischemia-induced enhancement of ASIC sensitivity, as well as neuronal death.

"In summary, our report provides a functional linkage betwe
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
22-Nov-2005


Page: 1 2

Related biology news :

1. Molecular detectors may refine cancer treatment
2. Story ideas from Molecular & Cellular Proteomics
3. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
4. Molecular motors may speed nutrient processing
5. Molecular rendezvous caught on camera
6. Molecular tools make the cut
7. Genomatix and Molecular Connections form strategic partnership
8. Molecular motors and brakes work together in cells
9. Molecular link between inflammation and cancer discovered
10. Molecular on/off switch controls immune defenses against viruses
11. Molecular marker on stem cells aids research, perhaps therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2020)... (PRWEB) , ... June 11, 2020 , ... ... DNA services, announces a significant expansion of its forensic genealogy team. Bode’s ... and attorneys through proven forensic genealogy and DNA analysis methods. The team has ...
(Date:6/11/2020)... ... , ... Superior Controls, Inc. , an E Technologies Company and leading ... sciences industry, is pleased to announce the recent hiring of Ray Boudreau, who will ... Hampshire office. In his new role, Boudreau will use his extensive experience with ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed to have ... our attendees, staff, and the public. We remain committed to creating a global ... collaborate virtually,” said Julie Sutcliffe, President of WMIS. , The abstract ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... WESTMINSTER, Colo. (PRWEB) , ... ... ... providers of expert tissue data insights, today announced that the launch of ... PD-L1 results along with data about the tumor microenvironment (TME). , “Flagship’s ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 pandemic ... drug treatment. In an effort to better understand the cellular responses to COVID-19, ... imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced molecules ...
(Date:6/28/2020)... ... 26, 2020 , ... The Security Industry Association ... opposition to the recently introduced bicameral Facial Recognition and Biometric Technology Moratorium ... use of nearly all biometric and related image analytics technologies, incorrectly labeling all ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... indoor environments, announced today that Derek Fournier has been appointed CEO and President. ... the Board, effective immediately. , “DeCurtis Corporation has been on an incredible ...
Breaking Biology Technology:
Cached News: