HOME >> BIOLOGY >> NEWS
Molecular detectors may refine cancer treatment

Gainesville, Fla. University of Florida researchers have successfully used molecular probes to detect subtle differences in leukemia cells from patient samples, an achievement that could lead to more effective ways to diagnose and treat cancer.

The strategy, described in a recent issue of Clinical Chemistry, involves engineering short, single strands of DNA or RNA called aptamers to seek out and bind with specific proteins in body fluids.

UF scientists designed the aptamers to bind to cells and molecules associated with leukemia, a cancer of the blood and bone marrow that annually claims about 21,000 lives in the United States, according to the National Cancer Institute.

Researchers also found the first evidence that slight molecular differences can exist even within the same samples from patients with adult T-cell leukemia, a cancer that strikes the immune systems own protective cells.

Our selective aptamers clearly confirm there are several subcategories of adult T-cell leukemia, said Weihong Tan, Ph.D., a UF Research Foundation professor of chemistry at the College of Liberal Arts & Sciences and a member of the UF Shands Cancer Center. At present, doctors have had only their experience to rely upon to determine the best treatment for these patients. Our findings will give doctors an effective tool to more precisely make a diagnosis and to tailor treatments.

UF researchers built designer probes using cancer cells as a template, capitalizing on the ability of aptamers to fold into well-defined, three-dimensional structures that bind to targets. The process relies on the fact that different types of cells exhibit unique surface features, so aptamers can recognize and bind with these target cells and only these cells even in the presence of other, closely related cells.

The scientists found that three of six aptamers they selected for study adhered to all types of cancerous cells but ignored normal b
'"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
19-Jul-2007


Page: 1 2

Related biology news :

1. Story ideas from Molecular & Cellular Proteomics
2. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
3. Molecular motors may speed nutrient processing
4. Molecular rendezvous caught on camera
5. Molecular tools make the cut
6. Genomatix and Molecular Connections form strategic partnership
7. Molecular motors and brakes work together in cells
8. Molecular link between inflammation and cancer discovered
9. Molecular on/off switch controls immune defenses against viruses
10. Molecular marker on stem cells aids research, perhaps therapies
11. Molecular mechanism provides intra-cellular traffic signal

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... FRANCISCO (PRWEB) , ... August 06, 2020 , ... ... life sciences industry, is pleased to announce that Eric Chen and Jessica Wong ... President of Product Management & Strategy, respectively. , Eric Chen heads development efforts ...
(Date:7/31/2020)... (PRWEB) , ... July 30, 2020 , ... ... Research (SBIR) Phase II contract awarded by the Joint Science & Technology Office—Chemical ... this project is to develop, optimize, and scale-up a highly efficient mammalian cell ...
(Date:7/18/2020)... (PRWEB) , ... July 17, 2020 , ... Commercial launch ... on pharma’s ability to discover a COVID cure or vaccine, the global economic downturn ... and price pressure is not going away and capturing full value from every product ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company ... Known as MediVet Biologics since its formation in 2016, the company is relaunching ... Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, ... have entered into a strategic partnership whereby Catalent will provide support for the ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and ... a great surgery is only the beginning of a successful study, while protecting and ... Join Brad Gien, Global Head of Surgery from Envigo in a ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... today that Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive ... PathSensors to move into the point-of-care diagnostic market, focusing initially on the ...
Breaking Biology Technology:
Cached News: