HOME >> BIOLOGY >> NEWS
Molecular detectors may refine cancer treatment

Gainesville, Fla. University of Florida researchers have successfully used molecular probes to detect subtle differences in leukemia cells from patient samples, an achievement that could lead to more effective ways to diagnose and treat cancer.

The strategy, described in a recent issue of Clinical Chemistry, involves engineering short, single strands of DNA or RNA called aptamers to seek out and bind with specific proteins in body fluids.

UF scientists designed the aptamers to bind to cells and molecules associated with leukemia, a cancer of the blood and bone marrow that annually claims about 21,000 lives in the United States, according to the National Cancer Institute.

Researchers also found the first evidence that slight molecular differences can exist even within the same samples from patients with adult T-cell leukemia, a cancer that strikes the immune systems own protective cells.

Our selective aptamers clearly confirm there are several subcategories of adult T-cell leukemia, said Weihong Tan, Ph.D., a UF Research Foundation professor of chemistry at the College of Liberal Arts & Sciences and a member of the UF Shands Cancer Center. At present, doctors have had only their experience to rely upon to determine the best treatment for these patients. Our findings will give doctors an effective tool to more precisely make a diagnosis and to tailor treatments.

UF researchers built designer probes using cancer cells as a template, capitalizing on the ability of aptamers to fold into well-defined, three-dimensional structures that bind to targets. The process relies on the fact that different types of cells exhibit unique surface features, so aptamers can recognize and bind with these target cells and only these cells even in the presence of other, closely related cells.

The scientists found that three of six aptamers they selected for study adhered to all types of cancerous cells but ignored normal b
'"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
19-Jul-2007


Page: 1 2

Related biology news :

1. Story ideas from Molecular & Cellular Proteomics
2. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
3. Molecular motors may speed nutrient processing
4. Molecular rendezvous caught on camera
5. Molecular tools make the cut
6. Genomatix and Molecular Connections form strategic partnership
7. Molecular motors and brakes work together in cells
8. Molecular link between inflammation and cancer discovered
9. Molecular on/off switch controls immune defenses against viruses
10. Molecular marker on stem cells aids research, perhaps therapies
11. Molecular mechanism provides intra-cellular traffic signal

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... , ... August 25, 2020 ... ... biotechnology company developing novel pharmaceuticals targeting mitochondria, in partnership with Essex Bio-Technology, ... in its pivotal U.S. Phase 3 VISTA-2 study of SkQ1 ophthalmic solution ...
(Date:8/21/2020)... CARLSBAD, Calif. (PRWEB) , ... August 19, 2020 ... ... of both Salimetrics LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for ... co-editor of the recently published book by Springer, " Salivary Bioscience: Foundations of ...
(Date:8/7/2020)... FRANCISCO (PRWEB) , ... August 06, 2020 , ... ... life sciences industry, is pleased to announce that Eric Chen and Jessica Wong ... President of Product Management & Strategy, respectively. , Eric Chen heads development efforts ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, ... that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... or two switches in a push-pull configuration; yielding fast fall time for a ...
(Date:7/31/2020)... (PRWEB) , ... July 30, ... ... of cloud-based software for the life sciences industry, today announced the release ... platform designed specifically for Medical Science Liaisons (MSLs) and other field medical ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... the life sciences and food industries, is pleased to announce that Charles Galea ... – Business Development. , Charles is an accomplished and results-driven sales executive with ...
(Date:7/7/2020)... DIEGO (PRWEB) , ... July 06, 2020 , ... R3 ... new program featuring up to 200 million stem cells. Depending on the patient's condition, ... seniors in the US will die having some form of Alzheimers dementia, and the ...
Breaking Biology Technology:
Cached News: