HOME >> BIOLOGY >> NEWS
Molecular mechanism provides intra-cellular traffic signal

City planners could learn a lesson or two from tiny cells on how to maximize traffic flow.

Researchers at the University of Illinois at Chicago have found that intra-cellular trafficking is tightly coordinated for maximum flow through cellular compartments -- much as vehicles on a crowded road are allowed to pass quickly through a succession of green traffic lights.

The molecular mechanism that underlies this coordination is reported by lead researcher Nava Segev, UIC professor of biological sciences, in the November issue of Nature Cell Biology.

While the finding was made using yeast cells, intra-cellular mechanisms discovered in yeast almost invariably correspond to processes in mammalian cells, including humans, and the mechanism Segev described may find applicability in the biomedical field.

"Every system in our body depends on intra-cellular trafficking, because anything that goes from the inside of a cell to the outside, or from outside to inside, uses this process," Segev said. "Malfunctioning of this pathway can cause a variety of human diseases. For example, problems in insulin secretion or presentation of insulin-receptors on the cell membrane result in diabetes. Defects in growth factor secretion and presentation of their receptors on cells result in cancer. Defects in neurotransmitter release or internalization result in brain disorders."

A special set of proteins is responsible for the coordination. Molecular switches that go by the letters Ypt allow membrane-enclosed vesicles to pass in and out of cellular compartments. Activator proteins flip the switches on. One activator protein, called TRAPP, coordinates two Ypt switches for quick entrance and subsequent exit from a central cellular compartment known as the Golgi apparatus.

"The Golgi is a central station in all cells, through which all intra-cellular traffic passes," Segev explained.

Specific subunits of TRAPP previously identifie
'"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
18-Oct-2006


Page: 1 2

Related biology news :

1. Molecular detectors may refine cancer treatment
2. Story ideas from Molecular & Cellular Proteomics
3. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
4. Molecular motors may speed nutrient processing
5. Molecular rendezvous caught on camera
6. Molecular tools make the cut
7. Genomatix and Molecular Connections form strategic partnership
8. Molecular motors and brakes work together in cells
9. Molecular link between inflammation and cancer discovered
10. Molecular on/off switch controls immune defenses against viruses
11. Molecular marker on stem cells aids research, perhaps therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... ... June 05, 2019 , ... ... exclusive financial advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by ... pathology platform that provides services to more than one dozen hospitals and surgery ...
(Date:6/4/2019)... ... 04, 2019 , ... Most preclinical EEG visualization platforms offer ... usually based on variations of amplitude, frequency or spike train detection. In the ... to the complexity and variability of the signal, and automation tools are used ...
(Date:5/31/2019)... (PRWEB) , ... May 29, 2019 , ... ... configurations on Mac, Windows and mobile, announces the launch of version 13.1. The ... the latest Android Management API, and supports Apple’s spring release functionality. Version 13.1 ...
Breaking Biology News(10 mins):
(Date:5/15/2019)... Pa. (PRWEB) , ... May 15, 2019 , ... Milton ... Year in recognition for his work within the biomedical industry, where he is changing ... improved medical devices. , “William Harding epitomizes the vision of our founders – ...
(Date:5/14/2019)... EGG HARBOR TOWNSHIP, N.J. (PRWEB) , ... May ... ... premier manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, ... a completely new Heliumleak.com company website. The redesigned website aims to improve LDA’s ...
(Date:5/8/2019)... ... ... Standing at 16.2 hands, Atlas is on the large side for a Quarter Horse. ... among other activities. When loping around a corner in late 2017, Atlas tripped and ... to only being able to walk. Fortunately Atlas’ owner, Kelly, sought the opinion of ...
(Date:5/4/2019)... ... May 03, 2019 , ... More than three thousand ... Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), during ... results of some research carried out by the association, in partnership with scientists ...
Breaking Biology Technology:
Cached News: