HOME >> BIOLOGY >> NEWS
Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves

Long distance messengers star in many heroic tales, perhaps the most famous being the one about the runner who carried the news about the victory of the Greeks over the Persians in the fateful battle of Marathon. A team of researchers at the Weizmann Institute of Science has now discovered how molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves.

A nerve cell has a cell body and a long extension, called an axon, which in humans can reach up to one meter in length. Nerve cells belonging to the peripheral nervous system can regrow when their axons are damaged. But how does the damaged axon inform the cell body that it must start producing vital proteins for the healing? That's precisely where the molecular messengers, proteins called Erk-1 and Erk-2, enter the picture. When the axon is injured, these proteins bind to molecules of phosphorus. In this phosphorylated state, they can communicate to command centers in the cell, transmitting a message that activates certain genes in the cell body, which then manufactures proteins that are vital for the healing of the injured axon. The problem is that the messengers must transmit their phosphorus message over a great distance along the axon, and in the course of this arduous journey can easily lose their phosphorus en route.

Dr. Michael Fainzilber and graduate students Eran Perlson and Shlomit Hanz of the Weizmann Institute's Biological Chemistry Department found that the Erk messengers, together with their phosphorus message, bind to a special molecule called vimentin, which protects them from dismantling or loss of the phosphorus. Vimentin links up to motor proteins that carry the message along the axon, and thanks to this linkage and protection, the messengers can safely transmit their message, thus bringing the injured axon's call for help to the cell body. The study will be published in the March 3'rd issue of Neuron. The scientists hope that these findings
'"/>

Contact: Alex Smith
asmith@jgordonassociates.com
212-367-3892
American Committee for the Weizmann Institute of Science
2-Mar-2005


Page: 1 2

Related biology news :

1. Molecular detectors may refine cancer treatment
2. Story ideas from Molecular & Cellular Proteomics
3. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
4. Molecular motors may speed nutrient processing
5. Molecular rendezvous caught on camera
6. Molecular tools make the cut
7. Genomatix and Molecular Connections form strategic partnership
8. Molecular motors and brakes work together in cells
9. Molecular link between inflammation and cancer discovered
10. Molecular on/off switch controls immune defenses against viruses
11. Molecular marker on stem cells aids research, perhaps therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/27/2019)... ... 2019 , ... Washington State University’s Center for Entrepreneurial Studies ... student venture teams, representing nearly 150 students, presented their business ideas and competed ... five teams in the College League were awarded prize money with Appiture winning ...
(Date:4/25/2019)... ... 2019 , ... NDA Partners Chairman Carl Peck, MD , announced today ... the development of drug and genomic diagnostic products for therapeutic indications in oncology, has ... Dr. Maddala served as Vice President of Biometrics at GRAIL, Inc., where she built ...
(Date:4/18/2019)... ... 18, 2019 , ... As the industry strengthens its focus ... that have the potential to increase patient recruitment and retention. However, despite its ... the complexity of regulations, potential cost implications and a multitude of other factors. ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... , ... May 03, 2019 , ... ... the President of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes ... in Brasília (DF). Urandir detailed the results of some research carried out by ...
(Date:5/2/2019)... ... April 30, 2019 , ... ... for Standardization ISO 9001:2015 standard, REPROCELL USA Inc. has demonstrated its ability ... addition, REPROCELL USA Inc. aims to enhance customer satisfaction through the effective ...
(Date:5/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical Trials – ...
(Date:5/2/2019)... ... May 02, 2019 , ... Boston Robotic Hair Restoration ... Gone are the days of painful hair transplant procedures. Boston Robotic Hair Restoration ... the only robotic intelligent solution to offer a minimally invasive procedure. With the ...
Breaking Biology Technology:
Cached News: