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Molecular motor helps cells tell which way is up

ous, the delivery process is essential. Loss of cell polarity is often the first step in converting a normal cell to a cancer cell, Chishti said.

The discovery illuminates a key step in the trafficking and disposition of polarity determinants. Science magazine highlighted the Chishti paper as an Editor's Choice in the August 18th issue and in this week's Signal Transduction Segment online at http://stke.sciencemag.org/.

"Now we know the cargo, and we know the motor," said Chishti. "The next step will be to find out what turns the motor on and tells it to start down the track to deliver the cargo.

"In the kinesin field, there are two fundamental questions: what are the cargoes, and what turns the motors on and off that carry them."


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Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
30-Aug-2006


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