HOME >> BIOLOGY >> NEWS
Molecular partners required for appropriate neuronal gene repression

PHILADELPHIA In their efforts to understand the complex biology of life, scientists often seek to isolate individual elements of the puzzle for study, to break the problem down to a more manageable size. Single genes and molecules are closely analyzed to better understand their specific interactions with other single entities within larger systems.

Sometimes, however, this approach misses important aspects of biology that depend on higher levels of organization. Sometimes putting a few of the pieces back together again reveals new information that would otherwise remain obscured.

A new study by researchers at The Wistar Institute demonstrates this point. Aiming for insights into the intricate biochemistry governing gene regulation, the scientists investigated the activity of a recently discovered enzyme pivotally involved in this process. A report on their findings, which may have long-term implications for treating depression and other psychiatric disorders, was published online by Nature today.

The enzyme's function is to remove methyl groups from histones to modify them in ways that trigger gene repression. Eight histones comprise a nucleosome, and long strings of nucleosomes coil in turn into chromatin, the basic material of chromosomes. In the body's scheme for safely storing genes away until needed, DNA is tightly looped around the histones, kept secure by enzymes similar to the one studied by the Wistar team until made accessible by the activity of related enzymes responsible for gene expression.

What the scientists found was that while the enzyme was able to demethylate its target histone when the pair was in isolation, it was unable to do so when the histone was placed in the more complex and realistic setting of a nucleosome. They then coupled the enzyme with other molecules with which it is known to complex to discover that one of them enabled the enzyme to act upon the histone and is, in fact, required for the enzyme's
'"/>

Contact: Franklin Hoke
hoke@wistar.org
215-898-3716
The Wistar Institute
3-Aug-2005


Page: 1 2

Related biology news :

1. Molecular detectors may refine cancer treatment
2. Story ideas from Molecular & Cellular Proteomics
3. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
4. Molecular motors may speed nutrient processing
5. Molecular rendezvous caught on camera
6. Molecular tools make the cut
7. Genomatix and Molecular Connections form strategic partnership
8. Molecular motors and brakes work together in cells
9. Molecular link between inflammation and cancer discovered
10. Molecular on/off switch controls immune defenses against viruses
11. Molecular marker on stem cells aids research, perhaps therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... August 06, 2020 , ... Alucio™, ... to announce that Eric Chen and Jessica Wong have joined the company’s leadership ... Strategy, respectively. , Eric Chen heads development efforts for Alucio’s flagship product, Beacon, ...
(Date:7/31/2020)... ... 30, 2020 , ... BioFactura, Inc. today announced a $1 ... Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the Department of Defense ... highly efficient mammalian cell culture-based bioprocess suitable to meet surge requirement needs for ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is ... ability to discover a COVID cure or vaccine, the global economic downturn will only ... pressure is not going away and capturing full value from every product launch is ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... entered into a strategic partnership whereby Catalent will provide support for the development, ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
Breaking Biology Technology:
Cached News: