HOME >> BIOLOGY >> NEWS
Molecular probes for biology research and drug discovery

While the field of genetics investigates and influences the life's processes by modifying the genes themselves, the field of chemical genetics pursues this goal using chemical compounds that modulate the functioning of the gene and its products (proteins, RNA, etc.). Therefore, chemists, biochemists and biologists from six Max Planck Institutes will work together in the new "Chemical Genomics Centre" in Dortmund in the search for small molecules that allow the study of fundamental life-science processes and the involved biological macromolecules. The Max Planck Society invests a total sum of 5 million euro. The chemical compounds will be designed and made based on natural products analogues, via combinatorial chemistry or rational design and their biological relevance will be tested subsequently in plants, animals and micro-organisms. In this way, molecules shall be identified that are capable of targeting disease relevant proteins or that are candidates for crop protection.

Image: Max Planck Institute for Molecular Physiology In the past decade it became increasingly clear that all biological processes in principal rely on chemical processes and are governed by the structure of the participating molecules and their interactions. Biological processes can be treated as chemical processes and studied in molecular detail. Nevertheless, up to today for only 500 of the over 100.00 proteins encoded by the human genome a chemical compound is known that interacts with and influences the protein. Therefore research following the sequencing of the genome is increasingly focussed on the function of its proteins and their interactions with small molecules (modulators). A new approach for this is Chemical Genomics. What is chemical genomics?

Chemical genomics uses drug-like molecules as modulating ligands for cell-biology research, to clarify for example the function of a certain gene product. For a long time such probe-molecules were only f
'"/>

Contact: Dr. Herbert Waldmann
herbert.waldmann@mpi-dortmund.mpg.de
49-231-133-2400
Max-Planck-Gesellschaft
26-Jan-2005


Page: 1 2 3 4 5

Related biology news :

1. Molecular detectors may refine cancer treatment
2. Story ideas from Molecular & Cellular Proteomics
3. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
4. Molecular motors may speed nutrient processing
5. Molecular rendezvous caught on camera
6. Molecular tools make the cut
7. Genomatix and Molecular Connections form strategic partnership
8. Molecular motors and brakes work together in cells
9. Molecular link between inflammation and cancer discovered
10. Molecular on/off switch controls immune defenses against viruses
11. Molecular marker on stem cells aids research, perhaps therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... 2020 , ... Alucio™, a fast-growing provider of cloud-based software ... Jessica Wong have joined the company’s leadership team as Vice President of Engineering, ... development efforts for Alucio’s flagship product, Beacon, an innovative cloud-based content management and ...
(Date:7/31/2020)... Md. (PRWEB) , ... July 30, 2020 , ... ... Innovation Research (SBIR) Phase II contract awarded by the Joint Science & Technology ... of this project is to develop, optimize, and scale-up a highly efficient mammalian ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is a critical stage ... a COVID cure or vaccine, the global economic downturn will only increase price pressures ... going away and capturing full value from every product launch is critical. However, history ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a highly regarded ... on the purchase of greenfield for a new, expanded manufacturing facility. The site ... acres in the initial acquisition, with an option to purchase an additional 21 ...
(Date:7/31/2020)... ... 2020 , ... R3 Stem Cell International is now offering patients the opportunity ... cells total, patients may choose which extremities they would like treated. , Several studies ... Disord. 2016). At R3 International, umbilical cord tissue is obtained from a lab with ...
(Date:7/31/2020)... ... 29, 2020 , ... Anomet Products has introduced new custom ... use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad ... performance, and cost criteria; especially where solid wire is limited. Typical configurations for ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... top radiation centers in 16 countries, has reached its 20th anniversary of worldwide ... in routine use at top universities including University of Pennsylvania, University of Michigan, ...
Breaking Biology Technology:
Cached News: