HOME >> BIOLOGY >> NEWS
Molecular switch provides clues to remarkable adaptability of human pathogen

Scientists have identified a gene that may play a key role in the ability of an important human pathogen to sense and adjust to its surroundings. The research, published in the November issue of Developmental Cell, provides new evidence about how bacteria regulate gene expression in response to changing environmental conditions to promote adaptation and long-term survival.

Pseudomonas aeruginosa is frequently found in soil, water, plants, and animals and can thrive in a wide variety of environments. P. aeruginosa also causes a variety of potentially fatal infections in humans with a disease- or injury-weakened immune system. In addition, infection with P. aeruginosa is the primary cause of death for patients with cystic fibrosis (CF), who often become infected shortly after birth and are afflicted with chronic persistent infection throughout their lives.

Dr. Stephen Lory and colleagues from the Department of Microbiology and Molecular Genetics at Harvard Medical School demonstrated that a P. aeruginosa gene product, called RetS, activates multiple genes known to be involved in host cell contact-dependent toxin secretion and mobility, processes required for acute infection. The researchers demonstrated that mice develop pneumonia after exposure to normal P. aeruginosa but are resistant to infection with a mutant variant of P. aeruginosa lacking RetS. Surprisingly, the less virulent P. aeruginosa with mutated RetS formed bacterial communities, called biofilms, much earlier than the normal bacteria. Formation of biofilms is associated with long-term chronic infection. The researchers used transcriptional profiling to show that RetS inhibited a collection of genes known to promote biofilm formation.

The researchers conclude that RetS activates multiple virulence factors that contribute to acute infection while simultaneously repressing those required for long-term, chronic infection. "This system functions as a multicomponent switch tha
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
8-Nov-2004


Page: 1 2

Related biology news :

1. Molecular detectors may refine cancer treatment
2. Story ideas from Molecular & Cellular Proteomics
3. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
4. Molecular motors may speed nutrient processing
5. Molecular rendezvous caught on camera
6. Molecular tools make the cut
7. Genomatix and Molecular Connections form strategic partnership
8. Molecular motors and brakes work together in cells
9. Molecular link between inflammation and cancer discovered
10. Molecular on/off switch controls immune defenses against viruses
11. Molecular marker on stem cells aids research, perhaps therapies

Post Your Comments:
(Date:7/23/2015)... , July 23, 2015 Research ... addition of the "Global Outlook of the ... offering. The global biometrics market ... public and commercial applications owing to the uptake ... witness a transformation that enhances the growth of ...
(Date:7/13/2015)... 13, 2015 Synaptics Inc. (NASDAQ: ... solutions, today announced sampling of ClearPad ® ... integration (TDDI) product targeting smartphones and tablets. This ... Synaptics , best-in-class touch controller IP and ... developed in the company,s Japan Design Center. TDDI ...
(Date:7/9/2015)... , July 9, 2015  Synaptics ... developer of human interface solutions, today announced ... industry,s first fully hardware encapsulated fingerprint sensor ... authentication technology is literally off the grid, ... biometric matching within the fingerprint sensor to ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
(Date:7/29/2015)... ... July 29, 2015 , ... ... announced its GHS Label Guide . To align chemical container labeling with ... guide includes explanations of label components, an example of an accurate label, and ...
(Date:7/29/2015)... , July 29, 2015  Therapath Neuropathology ... announces increased partnerships with VA and Military Medical ... Nerve Fiber Density (ENFD) and Sweat Gland Nerve ... fiber neuropathy ( https://therapath.com/skin ). ... Fiber Density (ENFD) on punch skin biopsy is ...
(Date:7/29/2015)... SLOUGH, England , July 29, 2015  Indivior ... Application (NDA) for naloxone nasal spray was accepted and ... Administration (FDA) for the treatment of opioid overdose. This ... contains naloxone specially formulated for optimal absorption into the ... to require minimal training so individuals may be better ...
(Date:7/29/2015)... July 29, 2015 /PRNewswire/ - RepliCel Life Sciences Inc. ... medicine company, is pleased to announce that the final ... have been locked.  Prototypes for industrial and regulatory ... an application for CE mark clearance to market ... in 2016. (Photo: http://photos.prnewswire.com/prnh/20150729/248373 )  ...
Breaking Biology Technology:Brady Announces a New GHS Label Guide 2Neuropathology services for VA and Military health systems 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 3Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 4Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 5RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5
Cached News: