HOME >> BIOLOGY >> NEWS
Molecular switch provides clues to remarkable adaptability of human pathogen

Scientists have identified a gene that may play a key role in the ability of an important human pathogen to sense and adjust to its surroundings. The research, published in the November issue of Developmental Cell, provides new evidence about how bacteria regulate gene expression in response to changing environmental conditions to promote adaptation and long-term survival.

Pseudomonas aeruginosa is frequently found in soil, water, plants, and animals and can thrive in a wide variety of environments. P. aeruginosa also causes a variety of potentially fatal infections in humans with a disease- or injury-weakened immune system. In addition, infection with P. aeruginosa is the primary cause of death for patients with cystic fibrosis (CF), who often become infected shortly after birth and are afflicted with chronic persistent infection throughout their lives.

Dr. Stephen Lory and colleagues from the Department of Microbiology and Molecular Genetics at Harvard Medical School demonstrated that a P. aeruginosa gene product, called RetS, activates multiple genes known to be involved in host cell contact-dependent toxin secretion and mobility, processes required for acute infection. The researchers demonstrated that mice develop pneumonia after exposure to normal P. aeruginosa but are resistant to infection with a mutant variant of P. aeruginosa lacking RetS. Surprisingly, the less virulent P. aeruginosa with mutated RetS formed bacterial communities, called biofilms, much earlier than the normal bacteria. Formation of biofilms is associated with long-term chronic infection. The researchers used transcriptional profiling to show that RetS inhibited a collection of genes known to promote biofilm formation.

The researchers conclude that RetS activates multiple virulence factors that contribute to acute infection while simultaneously repressing those required for long-term, chronic infection. "This system functions as a multicomponent switch tha
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
8-Nov-2004


Page: 1 2

Related biology news :

1. Molecular detectors may refine cancer treatment
2. Story ideas from Molecular & Cellular Proteomics
3. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
4. Molecular motors may speed nutrient processing
5. Molecular rendezvous caught on camera
6. Molecular tools make the cut
7. Genomatix and Molecular Connections form strategic partnership
8. Molecular motors and brakes work together in cells
9. Molecular link between inflammation and cancer discovered
10. Molecular on/off switch controls immune defenses against viruses
11. Molecular marker on stem cells aids research, perhaps therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
(Date:3/20/2017)... Germany , March 20, 2017 At this ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG ... is this year,s CeBIT partner country. At the largest German ... biometrics in use: fingerprint, face and iris recognition as well as DERMALOG´s ... ...
(Date:3/13/2017)... Germany , March 13, 2017 Future of security: ... ... DERMALOGs Face Matching enables to match face ... forms the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... , March 23, 2017  SeraCare ... to global in vitro diagnostics manufacturers and ... the industry,s first multiplexed Inherited Cancer ... testing by next-generation sequencing (NGS). The Seraseq™ ... developed with input from industry experts to ...
(Date:3/23/2017)... March 23, 2017  BioPharmX Corporation (NYSE MKT: ... the dermatology market, today reported financial results for ... and will provide an update on the company,s ... "We are pleased to report that ... BioPharmX," said President Anja Krammer. "We achieved key ...
(Date:3/23/2017)... , March 23, 2017 Kineta, Inc., ... of novel therapies in immuno-oncology, today announced the ... small molecule compounds that activate interferon response factor ... and demonstrate immune-mediated tumor regression in a murine ... study who demonstrated complete tumor regression to initial ...
(Date:3/23/2017)... ALBANY, New York , March 23, 2017 ... animal blood plasma products and derivatives market is fragmented due to the ... large players, such as Proliant, Thermo Fisher , and Sigma-Aldrich, ... clear leader, these three companies, collectively, held more than 76% of ... ...
Breaking Biology Technology:
Cached News: