HOME >> BIOLOGY >> NEWS
Molecular switch provides clues to remarkable adaptability of human pathogen

Scientists have identified a gene that may play a key role in the ability of an important human pathogen to sense and adjust to its surroundings. The research, published in the November issue of Developmental Cell, provides new evidence about how bacteria regulate gene expression in response to changing environmental conditions to promote adaptation and long-term survival.

Pseudomonas aeruginosa is frequently found in soil, water, plants, and animals and can thrive in a wide variety of environments. P. aeruginosa also causes a variety of potentially fatal infections in humans with a disease- or injury-weakened immune system. In addition, infection with P. aeruginosa is the primary cause of death for patients with cystic fibrosis (CF), who often become infected shortly after birth and are afflicted with chronic persistent infection throughout their lives.

Dr. Stephen Lory and colleagues from the Department of Microbiology and Molecular Genetics at Harvard Medical School demonstrated that a P. aeruginosa gene product, called RetS, activates multiple genes known to be involved in host cell contact-dependent toxin secretion and mobility, processes required for acute infection. The researchers demonstrated that mice develop pneumonia after exposure to normal P. aeruginosa but are resistant to infection with a mutant variant of P. aeruginosa lacking RetS. Surprisingly, the less virulent P. aeruginosa with mutated RetS formed bacterial communities, called biofilms, much earlier than the normal bacteria. Formation of biofilms is associated with long-term chronic infection. The researchers used transcriptional profiling to show that RetS inhibited a collection of genes known to promote biofilm formation.

The researchers conclude that RetS activates multiple virulence factors that contribute to acute infection while simultaneously repressing those required for long-term, chronic infection. "This system functions as a multicomponent switch tha
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
8-Nov-2004


Page: 1 2

Related biology news :

1. Molecular detectors may refine cancer treatment
2. Story ideas from Molecular & Cellular Proteomics
3. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
4. Molecular motors may speed nutrient processing
5. Molecular rendezvous caught on camera
6. Molecular tools make the cut
7. Genomatix and Molecular Connections form strategic partnership
8. Molecular motors and brakes work together in cells
9. Molecular link between inflammation and cancer discovered
10. Molecular on/off switch controls immune defenses against viruses
11. Molecular marker on stem cells aids research, perhaps therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... April 20, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, is pleased to announce ... of the new established USDM subsidiary “USDM Europe GmbH” based in Germany. , ...
(Date:4/20/2017)... CA (PRWEB) , ... April 20, 2017 , ... ... of clinical trials worldwide, announced today that they were named one of the ... which covers the latest developments in the pharmaceutical industry. , “We take pride in ...
(Date:4/19/2017)... ... 2017 , ... The Vibrating Orifice Aerosol Generator (VOAG) was ... droplets of known diameters for research applications such as for calibrating droplet measuring ... monodisperse droplets. , The VOAG requires forcing liquid out of an orifice ...
(Date:4/19/2017)... Waltham, MA (PRWEB) , ... April 19, 2017 ... ... of a $1.5M Series A-1 financing round. This event adds to several other ... establishment of its’ Executive and Scientific Teams. , ThermaGenix will use ...
Breaking Biology Technology:
Cached News: